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in Japanese PDF (45K)| ArticleTitle | Back to the Future: Pathophysiology and Therapeutic Strategies in Heart Failure |
| AuthorList | Yoshihiko Seino |
| Affiliation | First Department of Internal Medicine, Nippon Medical School |
| Language | JA |
| Volume | 71 |
| Issue | 6 |
| Year | 2004 |
| Page | 421-425 |
| Received | February 26, 2004 |
| Accepted | March 10, 2004 |
| Keywords | heart failure, evidence based medicine, beta-blocker, angiotensin receptor blockade, troponin T |
| Abstract | The present paper reviews the pathophysiology and therapeutic strategies in heart failure based on clinical investigations performed in our institute, and also recently reported large-scale double-blind clinical trials for the medical treatments of heart failure. Careful introduction of beta-blocker therapy along with RAAS inhibitors (ACE inhibitor, ARB, and/or aldosterone antagonist) should bring about marked improvement in mortality and morbidity in all subgroups of patients with heart failure. |
| Correspondence to | Yoshihiko Seino, MD, First Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan y-seino@nms.ac.jp |
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