-Short Communication-

Maternal Treatment with MCI-186 Does Not Improve Delayed Deterioration of Cellular Bioenergetic State and Mitochondrial Activity Following Transient Intrauterine Ischemia in the Fetal Rat Brain

Akishige Yokota, Akihito Nakai, Yoshinari Taniuchi, Naotaka Okuda, Masako Nakai and Toshiyuki Takeshita

Department of Obstetrics and Gynecology, Nippon Medical School

The mitochondrial respiratory activities and energy metabolism in the fetal rat brain were measured at the end of 30 minutes of intrauterine ischemia and after 2 and 4 hours of recirculation. The transient ischemia was associated with a delayed deterioration of cellular bioenergetic state and mitochondrial activities. The deterioration was not prevented by a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), given immediately after recirculation.

J Nippon Med Sch 2005; 72: 127-130

Keywords
mitochondrial respiratory activity, energy metabolism, intrauterine ischemia, fetal brain, hydroxyl radical, MCI-186

Correspondence to
Akihito Nakai, M.D., Department of Obstetrics and Gynecology, Tama Nagayama Hospital, Nippon Medical School, 1-7-1 Nagayama, Tama, Tokyo 206-8512, Japan
nakai-3@nms.ac.jp

Received, September 6, 2004
Accepted, February 15, 2005