-Original-

Effect of Bicarbonated Ringer's Solution on the Acid-base Balance in Patients Undergoing Abdominal Aortic Aneurysm Repair

Yoichi Shimada¹, Akira Kitamura², Kazuhiro Nakanishi², Takashi Hongo², Chol Kim² and Atsuhiro Sakamoto²

¹Department of Anesthesiology, Nippon Medical School Second Hospital
²Department of Anesthesiology, Nippon Medical School Hospital

Aim: The present study was designed to assess whether prophylactic use of bicarbonated Ringer's solution ameliorates metabolic acidosis in patients undergoing aortic surgery.
Methods: Twenty patients undergoing elective infrarenal aortic aneurysm repair were randomly assigned to receive either bicarbonated Ringer's solution or acetated Ringer's solution. The pH, PaCO₂, and base excess (BE) were measured before surgical incision (T0), 5 min before reperfusion (T1), 5 min after reperfusion (T2), and 30 min after reperfusion (T3). Data were compared between the two groups.
Results: Both pH and BE initially showed a slight decrease in both groups during clamping. After unclamping of the aorta, an additional decrease in pH was observed in both groups (T0 to T2, and T3). There were no significant differences in pH between the groups throughout the study period.
Conclusions: Aortic cross-clamping leads to the development of metabolic acidosis, with a decrease in pH and BE. The effect of administration of bicarbonated infusion fluid during elective abdominal aortic surgery had not significant compared with that of acetated Ringer's solution with respect to acid-base homeostasis.

J Nippon Med Sch 2005; 72: 364-369

Keywords
bicarbonated Ringer's solution, acetated Ringer's solution, acid-base balance

Correspondence to
Yoichi Shimada, MD, Department of Anesthesiology, Nippon Medical School Second Hospital, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan
megu@nms.ac.jp

Received, September 9, 2005
Accepted, October 25, 2005