-Report on Experiments and Clinical Cases-

Primary Pulmonary Mucosa-associated Lymphoid Tissue Lymphoma Combined with Idiopathic Thrombocytopenic Purpura and Amyloidoma in the Lung

Tetsuo Kawashima¹, Hitoshi Nishimura², Hirohiko Akiyama², Kyoji Hirai¹, Shigeki Yamagishi¹, Daisuke Okada¹, Hiroyasu Kinoshita¹, Yutaka Enomoto¹, Junichi Okamoto¹, Yuki Nakajima¹, Shingo Takeuchi¹, Yoshihito Iijima¹, Ken Furuhata¹, Keisuke Nakayama¹, Toshiyuki Izumo³, Kiyoshi Koizumi¹ and Kazuo Shimizu¹

¹Division of Thoracic Surgery, Department of Surgery, Nippon Medical School
²Department of Thoracic Surgery, Saitama Cancer Center
³Department of Pathology, Saitama Cancer Center

Three abnormal shadows were detected in the right lung on chest X-ray films and computed tomography in a 75-year-old woman during follow-up for idiopathic thrombocytopenic purpura. Because a definitive diagnosis was not obtained through general examinations, exploratory thoracotomy was performed for diagnosis and treatment. The main lesion in the right middle lobe was diagnosed as mucosa-associated lymphoid tissue (MALT) lymphoma according to histopathological findings, cytogenic studies and reverse transcriptase-polymerase chain reaction analysis, and nodular lesions in S³ and S⁷ were diagnosed with Congo-red staining as local deposition of amyloid. The patient had no recurrence of the MALT lymphoma of the lung or other organs for 4 years after surgery. To our knowledge, this is the first reported case of primary pulmonary MALT lymphoma combined with idiopathic thrombocytopenic purpura/lung amyloidoma.

J Nippon Med Sch 2005; 72: 370-374

Keywords
primary pulmonary mucosa-associated lymphoid tissue lymphoma, idiopathic thrombocytopenic purpura, amyloidosis

Correspondence to
Tetsuo Kawashima, MD, Division of Thoracic Surgery, Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
tkawa@nms.ac.jp

Received, July 21, 2005
Accepted, August 23, 2005