-Report on Experiments and Clinical Cases-

The Treatment of Refractory Pneumothorax in Diffuse Panbronchiolitis by Intravenous Administration of Coagulation Factor XIII Concentrate

Akira Murata, Ayumi Kouno, Kazuo Yamamoto, Hiroko Yoshioka, Kozui Kida and Shoji Kudoh

Department of Pulmonary Medicine, Infection and Oncology, Nippon Medical School

This case report presents a patient with advanced diffuse panbronchiolitis accompanied by chronic respiratory failure, marked cachexia, and refractory spontaneous pneumothorax. Because instillation of a pleurodesis agent and thoracoscopy were considered highly risky and invasive, we instead treated the patient with intravenous administration of a coagulation factor XIII concentrate, and the pneumothorax resolved. This case suggests refractory pneumothorax in a restrictive ventilatory disorder can be effectively treated with noninvasive intravenous administration of coagulation factor XIII concentrate.

J Nippon Med Sch 2006; 73: 89-92

Keywords
coagulation factor XIII, persistent air leak, intravenous administration, refractory peumothorax

Correspondence to
Akira Murata, Department of Pulmonary Medicine, Infection and Oncology, Nippon Medical School, JPR Ichigaya Building 8F, 4-7-15 Kudan-minami, Chiyoda-ku, Tokyo 102-0074, Japan
a-murata@nms.ac.jp

Received, December 13, 2005
Accepted, January 19, 2006