-Original-

Blood Glucose-lowering Activity of Colestimide in Patients with Type 2 Diabetes and Hypercholesterolemia: A Case-control Study Comparing Colestimide with Acarbose

Tatsuya Suzuki^1,2, Kenzo Oba^1,2, Shoko Futami^1,2, Kazunari Suzuki^1,2, Motoshi Ouchi^1,2, Yoshimasa Igari^1,2, Noriaki Matsumura^1,2, Kentaro Watanabe^1,2, Yoshiaki Kigawa^1,2 and Hiroshi Nakano^1,2

¹Department of Functional Pathophysiology for Human Organs, Nippon Medical School Graduate School of Medicine
²Division of Geriatric Medicine, Nippon Medical School

Background: An anion exchange resin has been reported to lower blood glucose levels in patients with type 2 diabetes.
Aim: To examine, in comparison with an α-glucosidase inhibitor, the usefulness of colestimide in lowering blood glucose levels in patients with type 2 diabetes and hypercholesterolemia.
Methods: Thirty-three patients with type 2 diabetes and hypercholesterolemia were more or less randomly assigned to receive either colestimide (17 patients) or acarbose (16 patients). At 10 time points before and after administration, plasma glucose levels and serum lipid concentrations were measured in all subjects, and the J-index and M-value were calculated.
Results: Patients receiving colestimide showed significant decreases in glucose levels 2 hours after breakfast (from 216.9 ± 37.2 mg/dl before treatment to 191.1 ± 40.9 mg/dl after treatment; p=0.008), in the J-index (from 42.6 ± 14.5 to 32.6 ± 9.8; p<0.001), and in the M-value (from 23.1 ± 12.1 to 14.6 ± 7.1; p<0.001).
Conclusion: In patients with type 2 diabetes and hyperlipidemia, colestimide was suggested to have blood glucose-lowering activity as does acarbose.

J Nippon Med Sch 2006; 73: 277-284

Keywords
colestimide, glycemic control, acarbose, type 2 diabetes mellitus

Correspondence to
Tatsuya Suzuki, Division of Geriatric Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
t-suzuki@nms.ac.jp

Received, June 23, 2006
Accepted, September 22, 2006