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Involvement of IGF-1/LARG Signaling in the Differentiation of Neural Stem Cells into Oligodendrocytes
Department of Bioregulation, Nippon Medical School
Neural stem cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that regulate the differentiation are not yet well understood. Insulin-like growth factor 1 (IGF-1) plays important roles during neuronal development. We examined the possibility that the IGF-1/leukemia-associated RhoGEF (LARG) pathway affects the differentiation of neural stem cells into oligodendrocytes. Characterization of cells positive for both IGF-1 receptor β and LARG in the subventricular zone during neuronal development suggests that IGF-1/LARG signaling is involved in oligodendrocyte differentiation from multipotent neural progenitor cells.
J Nippon Med Sch 2007; 74: 2-3
Correspondence to
Nobuchika Suzuki, Department of Bioregulation, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan
nobuchi@nms.ac.jp
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