-Original-

Relation of Leukocytosis in Prostatic Fluid and Inflamed Prostatic Tissue

Narumi Tsuboi¹, Taiji Nishimura¹, Haiwen Chen², Yoshihiko Norose³, Masumi Shimizu³, Yukihiro Kondo¹, Go Kimura¹ and Yu Fukuda⁴

¹Department of Urologic Surgery, Graduate School of Medicine, Nippon Medical School
²Department of Urology, Second Hospital, Xi'an Jiaotong University, China
³Department of Bioregulatory Science, Graduate School of Medicine, Nippon Medical School
⁴Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School

In our continuing investigation of the significance of leukocytosis in prostatic fluid (PF), the relation of leukocytosis in PF to that in selected sections of prostate with significant inflammation was studies with whole-mount specimens obtained at radical prostatectomy from 12 patients with prostate cancer. Although leukocytosis was observed both in PF and in prostate tissue in all 12 patients, there was no correlation between the leukocyte count in PF and the intensity of inflammation. However, the ratio of macrophages among leukocytes in PF correlated with the number of ducts filled with macrophages in prostate tissue (p=0.0481). This finding was consistent with our previous finding that activation of macrophages in PF reflects active inflammation in prostate tissue. Further studies are needed to clarify the roles of macrophages and whole leukocytes in PF and prostate tissue.

J Nippon Med Sch 2007; 74: 210-216

Keywords
prostatitis, prostatic fluid, macrophages, leukocytes, inflammation

Correspondence to
Taiji Nishimura, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
ben@nms.ac.jp

Received, January 5, 2007
Accepted, February 13, 2007