-Case Reports-

A Case of Sweet's Syndrome with Extensive Necrosis and Ulcers Accompanied by Myelodysplastic Syndrome

Tokue Kato¹, Seiji Kawana¹, Shin-ichiro Takezaki¹, Sachiko Kikuchi² and Ayako Futagami¹

¹Department of Cutaneous and Mucosal Pathophysiology, Graduate School of Medicine, Nippon Medical School
²Department of Ophthalmology, Graduate School of Medicine, Nippon Medical School

A 43-year-old woman presented with a persistent high fever of 39°C and edematous erythema accompanied by pustules on the face, trunk and extremities. Conjunctivitis and nodules were also observed in the right eye. On the basis of the clinical symptoms and histopathological findings. Sweet's syndrome was diagnosed. Eruptions quickly progressed to extensive necrosis and ulcers, mimicking clinical features of pyoderma gangrenosum. A bone marrow biopsy indicated myelodysplastic syndrome. Oral administration of 50 mg/day of prednisolone induced epithelialization of ulcers, with remaining scarring and pigmentation. Six months later, myelodysplastic syndrome had progressed to acute myelogenous leukemia.

J Nippon Med Sch 2008; 75: 162-165

Keywords
Sweet's syndrome, pyoderma gangrenosum, necrosis, myelodysplastic syndrome

Correspondence to
Tokue Kato, MD, Department of Dermatology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
tokue@nms.ac.jp

Received, January 10, 2008
Accepted, February 29, 2008