-Case Reports-

An Infant with Congenital Nemaline Myopathy and Hypertrophic Cardiomyopathy

Mizue Nakajima¹, Yoshio Shima¹, Sakae Kumasaka¹, Kentaro Kuwabara², Makoto Migita² and Yoshitaka Fukunaga²

¹Department of Pediatrics, Japanese Red Cross Katsushika Maternity Hospital
²Department of Pediatrics, Nippon Medical School

We describe an infant with nemaline myopathy accompanied by hypertrophic cardiomyopathy. The patient required long-term, intermittent positive-pressure ventilation after birth owing to muscle weakness, and cardiac failure developed during infancy. We diagnosed hypertrophic cardiomyopathy with outflow tract obstruction, and treated the heart failure with β-adrenergic and angiotensin II receptor blockers. We discuss the prognosis of nemaline myopathy combined with hypertrophic cardiomyopathy.

J Nippon Med Sch 2008; 75: 350-353

Keywords
nemaline myopathy, hypertrophic cardiomyopathy, early infancy

Correspondence to
Mizue Nakajima, Department of Pediatrics, Japanese Red Cross Katsushika Maternity Hospital, 5-11-12 Tateishi, Katsushika-ku, Tokyo 124-0012, Japan
s4019@nms.ac.jp

Received, May 7, 2008
Accepted, August 19, 2008