-Report on Experiments and Clinical Cases-

The Influence of Assisted Reproductive Technology on Women with Pregnancy-induced Hypertension: A Retrospective Study at a Japanese Regional Perinatal Center

Hidehiko Miyake^1,2, Nao Iwasaki¹, Akihito Nakai¹, Shunji Suzuki² and Toshiyuki Takeshita¹

¹Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School
²Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Tokyo

Objective: To evaluate clinical features of assisted reproductive technology (ART) patients with pregnancy-induced hypertension (PIH) compared to spontaneously conceived PIH patients.
Methods: We retrospectively compared PIH incidence, maternal outcomes, and neonatal outcomes among these patients.
Results: Preeclampsia, cesarean rate, and massive maternal bleeding were significantly more common in the ART group. Neonatal outcomes showed no significant difference between the groups. Multiple regression analysis revealed ART as an independent risk factor for preeclampsia. However, higher cesarean rate and massive bleeding were mainly associated with multiple pregnancy.
Conclusion: ART patients with PIH had an increased incidence of preeclampsia, cesarean delivery, and massive maternal hemorrhage.

J Nippon Med Sch 2010; 77: 312-317

Keywords
assisted reproductive technology, maternal outcome, perinatal outcome, pregnancy-induced hypertension

Correspondence to
Hidehiko Miyake, Department of Obstetrics and Gynecology, Nippon Medical School Tama Nagayama Hospital, 1-7-1 Nagayama, Tama, Tokyo 206-8512, Japan
hidehiko@pluto.dti.ne.jp

Received, June 1, 2010
Accepted, July 6, 2010