-Case Reports-

Conservative Management of Hyperreactio Luteinalis: A Case Report

Takashi Abe¹, Shuichi Ono¹, Miwa Igarashi¹, Shigeo Akira¹, Atsushi Watanabe² and Toshiyuki Takeshita¹

¹Division of Reproductive Medicine, Perinatology and Gynecologic Oncology, Graduate School of Medicine, Nippon Medical School
²Division of Clinical Genetics, Nippon Medical School

Hyperreactio luteinalis (HL) is characterized by bilaterally enlarged ovaries containing multiple self-limited theca lutein cysts and is usually associated with increased production of human chorionic gonadotropin in the presence of trophoblastic disease or multiple pregnancies. About 30 cases of HL have been reported in patients with normal singleton pregnancies, and most of these patients required surgical intervention during their first pregnancy because of ovarian torsion or to rule out of ovarian malignancy. However, the accurate diagnosis of HL by means of laboratory tests and magnetic resonance imaging and the exclusion of ovarian malignancy in asymptomatic pregnant woman may avoid unnecessary surgical intervention or termination of pregnancy. The present report describes case of HL in a woman with a normal singleton pregnancy in whom conservative management allowed the preservation of both ovaries.

J Nippon Med Sch 2011; 78: 241-245

Keywords
OHSS, FSH receptor, hyperandrogenism, pregnancy

Correspondence to
Takashi Abe, MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
takashi360@nms.ac.jp

Received, December 15, 2010
Accepted, March 2, 2011