-Review-

Pathophysiology of Functional Dyspepsia

Seiji Futagami¹, Mayumi Shimpuku¹, Yan Yin², Tomotaka Shindo¹, Yasuhiro Kodaka¹, Hiroyuki Nagoya¹, Shoko Nakazawa¹, Mayumi Fujimoto¹, Nikki Izumi¹, Noriko Ohishi¹, Tetsuro Kawagoe¹, Akane Horie¹, Katsuhiko Iwakiri¹ and Choitsu Sakamoto¹

¹Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
²Division of Gastroenterology, Department of Internal Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, People's Republic of China

Functional dyspepsia is a highly prevalent and heterogeneous disorder. Functional dyspepsia involves many pathogenic factors, such as gastric motility disorders, visceral hypersensitivity, psychological factors, Helicobacter pylori infection, and excessive gastric acid secretion. The present article provides an overview of pathogenetic factors and pathophysiologic mechanisms.

J Nippon Med Sch 2011; 78: 280-285

Keywords
functional dyspepsia, gastric emptying, ghrelin, post-infectious functional dyspepsia

Correspondence to
Seiji Futagami, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
seiji.futagami@gmail.com

Received, July 21, 2011
Accepted, August 25, 2011