-Original-

The Effect of Maximum Voided Volume on Response to Desmopressin Therapy in Children with Enuresis

Mesut Okur¹, Semiha Fatma Ozen¹, Kenan Kocabay¹, Kamil Cam², Aybars Ozkan³ and Hakan Uzun¹

¹Department of Pediatrics, Duzce University Medical Faculty, Turkey
²Department of Urology, Duzce University Medical Faculty, Turkey
³Department of Pediatric Surgery, Duzce University Medical Faculty, Turkey

Purpose: This study was aimed to determine the effect of maximum voided volume (MVV) on the efficacy of desmopressin, which is commonly used to treat primary monosymptomatic nocturnal enuresis (PMNE) in children and adolescents.
Materials and Methods: Bladder capacity was measured with different methods in 52 patients with PMNE, and the effect of bladder capacity on desmopressin therapy was investigated.
Results: Patients with PMNE in whom MVV was 70% or less of estimated bladder capacity were found to be unresponsive to desmopressin therapy.
Conclusion: The MVV can be measured before desmopressin therapy in patients with PMNE as a marker to predict treatment success. Our results suggest that desmopressin should not be used in patients with low MVV.

J Nippon Med Sch 2012; 79: 255-258

Keywords
enuresis nocturna, desmopressin, maximum voided volume, children

Correspondence to
Mesut Okur, MD, Department of Pediatrics, Duzce University Medical Faculty, 81620 Konuralp-Düzce, Turkey
okurmesut@yahoo.com

Received, October 18, 2011
Accepted, January 6, 2012