-Case Reports-

A Case of Gastric Cancer with Perforation Caused by Chemotherapy with Docetaxel and S-1

Takeshi Yamada¹, Yoshikazu Kanazawa¹, Kimiyoshi Yokoi² and Eiji Uchida¹

¹Department of Surgery, Nippon Medical School
²Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital

We treated a patient who had gastrointestinal perforation during chemotherapy with docetaxel and S-1 which was successfully treated with percutaneous drainage. A 66-year-old man was admitted to our hospital with complaints of abdominal pain. Gastric cancer (T3N1M0) had been diagnosed 3 years earlier, and distal gastrectomy had been performed. Two years later, intrapelvic recurrence of the cancer was diagnosed. We administered docetaxel and S-1. After 3 courses of chemotherapy, he complained of abdominal pain of sudden onset. Computed tomography showed free air and limited ascites, and gastrointestinal perforation was diagnosed. We performed percutaneous drainage. The abdominal pain improved 3 days later, and he was able to eat meals 15 days after the onset of abdominal pain. He was discharged 27 days after admission. Because the patient's general condition was poor, we started providing best supportive care only. He died 10 months after the perforation was found.

J Nippon Med Sch 2013; 80: 451-455

Keywords
gastric cancer, gastrointestinal perforation, docetaxel, S-1

Correspondence to
Takeshi Yamada, MD, Department of Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
y-tak@nms.ac.jp

Received, May 28, 2012
Accepted, January 5, 2013