-Case Reports-

Poststreptococcal Glomerulonephritis in a Patient with Essential Thrombocytosis

Sukru Ulusoy¹, Gulsum Ozkan², Mehmet Sonmez³, Sevdegül Mungan⁴, Rahman Köseoğlu⁵, Muammer Cansız¹ and Kübra Kaynar¹

¹Department of Nephrology, School of Medicine, Karadeniz Technical University, Turkey
²Department of Nephrology, Hatay Antakya State Hospital, Turkey
³Department of Hematology, School of Medicine, Karadeniz Technical University, Turkey
⁴Department of Patholology, School of Medicine, Karadeniz Technical University, Turkey
⁵Department of Internal Medicine, School of Medicine, Karadeniz Technical University, Turkey

In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3.5 years. These characteristics make our case the first to be reported in the literature.

J Nippon Med Sch 2015; 82: 59-63

Keywords
essential thrombocytosis, glomerulonephritis, myeloproliferative neoplasm, poststreptococcal glomerulonephritis

Correspondence to
Sukru Ulusoy, MD, Department of Nephrology School of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
sulusoy2002@yahoo.com

Received, April 9, 2014
Accepted, August 20, 2014