-Case Reports-

Refractory Leg Ulcers Associated with Klinefelter Syndrome

Yuto Yabuno¹, Mamiko Tosa¹, Itaru Iwakiri¹, Shunichi Nomoto¹, Mayuko Kaneko¹, Kousuke Kuwahara¹, Hiko Hyakusoku² and Masahiro Murakami¹

¹Department of Plastic and Reconstructive Surgery, Nippon Medical School Musashi Kosugi Hospital
²Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School

We present a man with refractory leg ulcers, bilateral varicosis of the lower extremities, and Buerger disease. Autoimmune work-up was negative. However, chromosome analysis showed Klinefelter syndrome (48 XXY). Ulcerative lesions of the lower extremities are a complication of Klinefelter syndrome. To date, the pathogenesis of ulcers in Klinefelter syndrome has not been clarified, but several factors, such as abnormalities of fibrinolysis and prothrombotic states, might be involved. Our present case emphasizes the importance of considering Klinefelter syndrome in the differential diagnosis of a male patient with nonhealing ulcers of the lower extremities.

J Nippon Med Sch 2015; 82: 64-67

Keywords
Klinefelter syndrome, refractory leg ulcer, XXY, fibrinolysis, prothrombotic state

Correspondence to
Yuto Yabuno, MD, Department of Aesthetic and Plastic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
yabuno@nms.ac.jp

Received, May 21, 2014
Accepted, September 22, 2014