-Case Reports-

Seronegative Antiphospholipid Syndrome with Anti-phosphatidylethanolamine Antibody in a Boy

Takeshi Asano¹, Hidehiko Narazaki¹, Kiyohiko Kaizu¹, Kentaroh Kuwabara², Osamu Fujino¹ and Yasuhiko Itoh²

¹Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital
²Department of Pediatrics, Nippon Medical School

Antiphospholipid syndrome (APS) is an autoimmune disease caused by antiphospholipid antibodies. At our institution, APS is diagnosed on the basis of the Sapporo criteria, which consist of thrombosis and recurrent pregnancy-related complications and the following laboratory findings: the presence of lupus anticoagulant, anticardiolipin antibody, or anti-β2 glycoprotein 1 antibody. However, we sometimes treat patients we strongly suspect of having APS but who do not satisfy the laboratory criteria. To accommodate such suspected cases, a subtype of APS termed seronegative APS has been proposed. Here, we report on a man with chronic thromobocytopenic purpura since the age of 3 years and multiple cerebral infarctions since the age of 14 years who finally received a diagnosis of seronegative APS with positive antiphosphatidylethanolamine antibodies.

J Nippon Med Sch 2015; 82: 117-120

Keywords
antiphosphatidylethanolamine antibody, chronic thrombocytopenia, cerebral infarctions, seronegative antiphospholipid syndrome

Correspondence to
Takeshi Asano, MD, Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan
VFF13540@nifty.ne.jp

Received, August 17, 2014
Accepted, November 12, 2014