-Case Reports-

A Case Report and a Short Literature Review of Pulmonary Sequestration Showing Elevated Serum Levels of Carbohydrate Antigen 19-9

Jiajia Dong^1-3, Yijing Cai^1-3, Ruicong Chen^1-3, Shanjie Du^1-3, Yongping Chen^1-3 and Keqing Shi^1-3

¹Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, P.R. China
²Wenzhou Key Laboratory of Hepatology
³Hepatology Institute of Wenzhou Medical University

Pulmonary sequestration is a type of bronchopulmonary malformation defined as an isolated portion of lung tissue with systemic arterial supply and no bronchial communication. Carbohydrate antigen 19-9 (CA19-9) has been used for diagnosis and follow-up of gastrointestinal tumors. The current study presents a rare case of intralobar pulmonary sequestration associated with the marked elevation of CA19-9. A 39-year-old female patient was admitted to our hospital due to acute liver injury with marked elevation of serum CA19-9 (3,051.1 μmol/mL), and was then diagnosed with intralobar pulmonary sequestration after examination and surgery. After the pulmonary resection, the serum CA19-9 levels decreased to normal ranges. We briefly reviewed the literature on elevated serum CA19-9 levels and pulmonary sequestration since 1988. We found that serum CA19-9 levels are increased not only in patients with digestive tract cancers but also in those with nonmalignant diseases such as pulmonary sequestration.

J Nippon Med Sch 2015; 82: 211-215

Keywords
pulmonary sequestration, carbohydrate antigen 19-9, digestive tract cancers

Correspondence to
Keqing Shi, Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, Zhejiang, 325000, P.R. China
skochilly@163.com

Received, September 11, 2014
Accepted, February 16, 2015