-Case Reports-

A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin

Akiko Kanzaki¹, Shin-ichi Ansai², Takashi Ueno¹, Seiji Kawana¹, Akira Shimizu³, Zenya Naito³ and Hidehisa Saeki¹

¹Department of Dermatology, Nippon Medical School, Tokyo, Japan
²Division of Dermatology, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan
³Division of Diagnostic Pathology, Nippon Medical School, Tokyo, Japan

A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Histology of the biopsy showed a nodular and morpheic basal cell carcinoma (BCC). A chest computed tomography (CT) scan showed multiple lung tumors. CT-guided biopsy of the lung and the cervical lymph node revealed metastatic basal cell carcinoma (MBCC). The primary skin tumor was resected and a total of 10 courses of cisplatin (25 mg/m²/day×75%) and adriamycin (50 mg/m²×75%) were administered for metastatic basal cell carcinoma (MBCC). The patient died 5 years and 3 months after his first visit. Autopsy revealed MBCC in the lung, kidney, pancreas, several lymph nodes, liver and bone. A portion of the tumor cells were composed of squamoid cells with eosinophilic cytoplasm, large nuclei, lack of the characteristic peripheral palisading and retraction artifacts, and variable cytoplasmic keratinization. These pathological findings were compatible with basosquamous cell carcinoma. Chemotherapy was effective for MBCC in this patient.

J Nippon Med Sch 2017; 84: 286-290

Keywords
metastatic basal cell carcinoma, cisplatin, adriamycin, lung metastasis, lymph node metastasis

Correspondence to
Akiko Kanzaki, Department of Dermatology, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
konchi@nms.ac.jp

Received, March 21, 2017
Accepted, August 8, 2017