-Case Reports-

Acute Kidney Injury in a Case of Purpura Fulminans Developing Secondary to Antithrombin 3 Deficiency

Gülsüm Özkan¹, Gaye Kübra Emeksiz², Reşit Volkan Atar², Samet Sedef², Pınar Sonat Kara², Meltem Öznur³ and Burhan Turgut⁴

¹Department of Nephrology, Namık Kemal University, School of Medicine, Tekirdağ, Turkey
²Department of Internal Medicine, Namık Kemal University, School of Medicine, Tekirdağ, Turkey
³Department of Pathology, Namık Kemal University, School of Medicine, Tekirdağ, Turkey
⁴Department of Hematology, Namık Kemal University, School of Medicine, Tekirdağ, Turkey

Purpura fulminans associated with antithrombin 3 (AT 3) deficiency is very rare in adults and neonates. It can be categorized into three principal forms - neonatal, idiopathic and acute infectious. Purpura fulminans has been reported to cause cardiac, pulmonary and renal damage in rare cases. We describe an adult case of purpura fulminans developing in association with AT 3 deficiency without infection following a surgical procedure, and acute kidney injury (AKI) developing secondary to rhabdomyolysis and disseminated intravascular coagulation (DIC). To the best of our knowledge there have been no previous cases of purpura fulminans and AKI developing in association with acquired AT 3 deficiency without infection after surgery.

J Nippon Med Sch 2018; 85: 56-59

Keywords
purpura fulminans, acute kidney injury, antithrombin 3 deficiency

Correspondence to
Dr. Gülsüm Özkan, Department of Nephrology, Namık Kemal University, School of Medicine, 59000 Tekirdağ , Turkey
gulsumozkan78@hotmail.com

Received, August 2, 2017
Accepted, October 2, 2017