-Review-

Comparison of Functional Dyspepsia and Early Chronic Pancreatitis

Seiji Futagami, Hiroshi Yamawaki, Shuhei Agawa, Go Ikeda, Hiroto Noda, Kumiko Kirita, Kazutoshi Higuchi, Katya Gudis, Makoto Murakami, Yasuhiro Kodaka, Nobue Ueki and Katsuhiko Iwakiri

Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, Tokyo, Japan

Functional dyspepsia (FD) is a common disease that can markedly impair quality of life. In the 2016 Rome IV criteria, a diagnosis of FD requires the presence of bothersome FD symptoms. In 2009, a new diagnosis, early chronic pancreatitis (ECP), was proposed as a means to facilitate early treatment of chronic pancreatitis and prevent progression to chronic pancreatitis. Although chronic pancreatitis was reported to be a cause of dyspepsia, data on the relation between ECP and FD patients are limited. We therefore investigated differences between ECP patients and FD patients in the percentages of those with severe epigastric pain, early satiety, and postprandial abdominal fullness. Several studies reported an association between the cause of chronic pancreatitis and endosonographic features. In addition, endosonography was useful for distinguishing ECP patients from FD patients with pancreatic enzyme abnormalities. Thus, we compared endosonographic characteristics in these patient groups. Future studies should attempt to determine why selected FD patients with pancreatic enzyme abnormalities develop ECP.

J Nippon Med Sch 2020; 87: 2-6

Keywords
functional dyspepsia, early chronic pancreatitis, endosonography, GLP-1

Correspondence to
Seiji Futagami, MD, PhD, Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
seiji.futagami@gmail.com

Received, January 15, 2019
Accepted, July 24, 2019