-Case Reports-

Effect of Tranexamic Acid for Traumatic Brain Injury: A Case Report

Toru Miike, Yuichiro Sakamoto and Satoshi Inoue

Center for Emergency and Critical Care Medicine, Saga University Hospital, Saga, Japan

Traumatic brain injury (TBI) often results in coagulopathy, which increases mortality risk. The Clinical Randomization of an Antifibrinolytic in Significant Head injury (CRASH)-2 and CRASH-3 trials confirmed that tranexamic acid (TXA) was effective after trauma. Herein, we report a unique coagulation change in a patient with TBI given TXA after point-of-care assessment. Coagulation functions were impaired on admission. At 1 hour after TXA administration, clotting time was further prolonged in the extrinsic coagulation pathway but shortened in the intrinsic coagulation system. The results of a test of the total thrombus-formation analysis system showed improved blood clot formation ability. Intrinsic coagulation and clot formation improved after TXA administration in a TBI patient with coagulopathy.

J Nippon Med Sch 2020; 87: 227-232

Keywords
traumatic brain injury, tranexamic acid, coagulation function

Correspondence to
Toru Miike, MD, PhD, Assistant Professor, Department of Emergency and Critical Care Medicine Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, Saga 849-8501, Japan
miike@cc.saga-u.ac.jp

Received, December 3, 2019
Accepted, March 26, 2020