-Original-

Growth Hormone Treatment at Nippon Medical School Chiba Hokusoh Hospital

Eri Kuramochi, Kazuya Mae, Yuuka Ohtomo, Reina Kamada, Hanako Sugano-Tajima and Takeshi Asano

Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan

Background: Since 2002, the Department of Pediatrics of Nippon Medical School Chiba Hokusoh Hospital has offered educational activities for children with short stature. We analyzed outcomes of growth hormone (GH) treatment for children with short stature treated at our hospital, particularly outcomes after the growth spurt.
Methods: We analyzed data from children aged 0 to 17 years who were treated with recombinant GH during the period from 2000 through 2016 and were followed for at least 2 years after the start of treatment.
Results: Among children with short stature, 85 had GH deficiency, 5 had Turner syndrome, 9 were small for gestational age, and 1 had Noonan syndrome. The outcomes of GH treatment was similar to those previously reported in Japan. Children with GH deficiency who started GH treatment before the growth spurt exhibited marked height catch-up until the second year, but the effect decreased after 3 years. The effect of treatment for GH deficiency that was started after the growth spurt continued for 4 to 5 years after the start of treatment.
Conclusions: Improvement in height standard deviation score was similar when treatment was started before and after the growth spurt.

J Nippon Med Sch 2021; 88: 39-44

Keywords
short stature, growth hormone deficiency, recombinant growth hormone treatment

Correspondence to
Takeshi Asano, MD, Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inzai, Chiba 270-1694, Japan
July1364@nms.ac.jp

Received, October 1, 2019
Accepted, February 26, 2020