-Original-

Prognostic Factors and Prediction of Survival for Patients with Brain Metastases of Lung Adenocarcinoma

Rongjiong Zheng¹, Dina Guo¹, Yongquan Dong¹, Mingming Wang¹, Meiling Hu² and Yifeng Ren¹

¹Department of Pulmonology, Ningbo Yinzhou No 2. Hospital, Ningbo, China
²Cixi People's Hospital of Zhejiang Province, Zhejiang, China

Background: The study aimed to identify risk factors associated with overall survival (OS) of patients with lung adenocarcinoma (LACA) with brain metastasis and developed a prognostic tool (nomogram) for these patients.
Methods: LACA patients with brain metastases between 2010 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier analysis and a Cox regression model were used to assess the prognostic effect of variables on survival rate. A nomogram was developed to predict 3-, 6- and 9-month OS rates.
Results: 2,631 LACA patients with brain metastases were studied. A nomogram was developed by using variables that affected OS and was validated by internal bootstrap resampling, which revealed that the nomogram had satisfactory discrimination.
Conclusions: The nomogram was able to predict 3-, 6- and 9-month OS for patients with LACA and brain metastases.

J Nippon Med Sch 2021; 88: 319-325

Keywords
nomogram, lung adenocarcinoma, brain metastases, hazards model, SEER database

Correspondence to
Yifeng Ren, MD, Ningbo Yinzhou No 2. Hospital, Ningbo 1 Qianhe Road, Ningbo, 315192, China
84479482@qq.com

Received, January 14, 2020
Accepted, September 11, 2020