-Case Reports-

Treatment of Carcinosarcoma of the Fallopian Tube Mimicking Ovarian Cancer: A Case Report and Genetic Analysis

So-Woon Kim¹ and Youngsun Kim²

¹Department of Pathology, Kyung Hee Medical Center, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
²Department of Obstetrics and Gynecology, Kyung Hee Medical Center, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

Carcinosarcoma of the fallopian tube is an exceptionally rare gynecological neoplasm. It tends to have high metastatic potential, to frequently recur, and has a poor prognosis. For these reasons, treatment is difficult and there is no standardized therapy schedule for this disease. Here, we report a case of carcinosarcoma of the fallopian tube mimicking ovarian cancer, initially presenting as a rupture of a growth and subsequent hemoperitoneum. The 55-year-old woman underwent cytoreductive surgery and postoperative conventional platinum-based combination therapy. The anti-angiogenic drug bevacizumab was added, and no evidence of disease was found on follow-up images or tumor markers 51 months after surgical resection. We describe a rare case of carcinosarcoma of the fallopian tube, include an in-depth histopathological review with genetic analysis, and propose treatment with a platinum-based combination therapy including bevacizumab.

J Nippon Med Sch 2021; 88: 574-578

Keywords
bevacizumab, carcinosarcoma, fallopian tube, ovarian cancer, platinum

Correspondence to
Youngsun Kim, Department of Obstetrics and Gynecology, Kyung Hee Medical Center, College of Medicine, Kyung Hee University, Kyungheedaero 23, Dongdaemungu, Seoul , Republic of Korea
chacha0725@naver.com

Received, August 27, 2020
Accepted, December 11, 2020