-Review-

Multiscale Aspects of Molecular Motions: From Molecular Vibrations, Conformational Changes of Biomolecules to Cellular Dynamics

Hiroshi Fujisaki^1,2

¹Department of Physics, Nippon Medical School, Tokyo, Japan
²AMED-CREST, Japan Agency for Medical Research and Development, Japan

Molecular aspects of living systems are important because it is the most basic aspects of life as exemplified in biochemistry and structural biology. Since molecules move due to interactive forces between atoms, physics plays an important role to understand the dynamic phenomena of living systems. Here we review our multiscale approaches for computationally treating different levels of molecular motions: vibrational dynamics of molecules, conformational change of biomolecules, and cellular dynamics using statistical-mechanics-based models.

J Nippon Med Sch 2022; 89: 9-15

Keywords
computer simulations, molecular vibration, quantum dynamics, conformational change, cellular dynamics

Correspondence to
Hiroshi Fujisaki, Department of Physics, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-0023, Japan
fujisaki@nms.ac.jp

Received, April 6, 2021
Accepted, June 11, 2021