-Original-

Associations of AminoIndex Cancer Screening (Breast) Grade with Clinical and Laboratory Variables

Tomoo Jikuzono^1-3, Osamu Ishibashi^1,2, Shoko Kure⁴, Yumi Ohmae³ and Toshimichi Ohmae^3,5

¹Department of Endocrine Surgery, Nippon Medical School, Tokyo, Japan
²Laboratory of Biological Macromolecules, Department of Applied Life Sciences, Graduate School of Life & Environmental Sciences, Osaka Prefecture University, Osaka, Japan
³Shin-urayasu Toranomon Clinic, Chiba, Japan
⁴Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, Japan
⁵Shisui Toranomon Clinic, Chiba, Japan

Background: Altered metabolism in the blood of cancer patients is closely related to changes in amino acids. Amino acids play an important physiological role as essential metabolites and regulators of metabolism. AminoIndex Cancer Screening (AICS) uses multivariate analysis of plasma-free amino acid profiles to screen for seven cancer types, including breast cancer.
Methods: To determine the clinical utility of AICS (breast), we retrospectively analyzed associations of AICS (breast) score with clinical and laboratory variables in 390 patients who underwent AICS (breast) testing. The mean age of participants was 50.7 years (range: 26-87 years) and all were female.
Results: The AICS (breast) grade was A, B, and C for 250 (64.1%), 90 (23.1%), and 50 (12.8%) participants, respectively. AICS (breast) was significantly correlated with AICS (gastric) (r = 0.487, p < 0.0001) and AICS (lung) (r = 0.523, p < 0.0001). Multivariate linear regression analysis showed no significant difference of AICS (breast) grade with age, body mass index, estimated glomerular filtration rate, dyslipidemia, or blood pressure. However, neutrophil-to-lymphocyte ratio significantly differed in relation to AICS (breast) grade (cut-off value, 1.7; p = 0.030), although only data from 72 patients were analyzed.
Conclusion: To our knowledge, this is the first study to report associations of AICS (breast) grade with clinical variables.

J Nippon Med Sch 2022; 89: 377-383

Keywords
AminoIndex Cancer Screening, breast cancer, neutrophil to lymphocyte ratio

Correspondence to
Tomoo Jikuzono, MD, PhD, Department of Endocrine Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
t-jikuzono@nms.ac.jp

Received, September 16, 2021
Accepted, December 15, 2021