-Original-

The Prognostic Nutritional Index as a Predictor of Gastric Cancer Progression and Recurrence

Kentaro Maejima^1,2, Nobuhiko Taniai² and Hiroshi Yoshida³

¹Department of Surgery, Hasuda Hospital, Saitama, Japan
²Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School Musashikosugi Hospital, Kanagawa, Japan
³Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School Hospital, Tokyo, Japan

Background: Gastric cancer can recur soon after treatment. We evaluated the prognostic nutritional index (PNI), a predictor of postoperative complications, and examined the association of PNI with progression and recurrence of gastric cancer.
Methods: We retrospectively investigated data from 697 patients who had undergone surgery for gastric carcinoma (excluding those with stage IV disease) and analyzed associations of age, sex, performance status (PS), American Society of Anesthesiologists (ASA) classification, diabetes, depth of main tumor (T), lymph node metastasis, postoperative complications, recurrence, and survival with PNI. We also performed multivariate analysis to identify factors associated with survival.
Results: PNI significantly decreased with age and was significantly lower in women. PNI was significantly positively correlated with PS. PNI was significantly lower for ≥T2 cancers and in patients with lymph node metastasis. There was no association between postoperative complications and PNI. PNI was significantly lower for patients who developed recurrence than for those who did not. The survival rate was examined for groups with a PNI of ≥45 (high PNI) and <45 (low PNI). Both 5-year overall survival (OS) and cancer-specific survival (CS) were significantly worse for the low PNI group. Multivariate analysis showed that PNI was an independent predictor of OS and CS.
Conclusions: PNI was associated with progression and recurrence of gastric cancer.

J Nippon Med Sch 2022; 89: 487-493

Keywords
gastric cancer, prognostic nutritional index (PNI), surgery

Correspondence to
Kentaro Maejima, Department of Surgery, Hasuda Hospital, 1-1662 Negane, Hasuda, Saitama 349-0131, Japan
ken3363-attacker@nms.ac.jp

Received, January 13, 2022
Accepted, March 23, 2022