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Associations of Nutrients and Dietary Preferences with Recurrent Pregnancy Loss and Infertility
1Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan
2Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan
3Takeshita Ladies Clinic, Tokyo, Japan
*Contributed equally
This review examines associations of nutrients and dietary preferences with recurrent pregnancy loss (RPL), miscarriage, and infertility. Research articles, reviews, and meta-analyses of RPL and infertility that focused on nutrition, meals, and lifestyle were reviewed, and associations of nutrients and dietary preferences with pregnancy are discussed in relation to recent research findings. Studies related to RPL were given the highest priority, followed by those dealing with miscarriage and infertility. Multivitamin supplements-even when lacking folic acid or vitamin A-reduced total fetal loss. High-dose folic acid supplementation before conception reduced the risk of miscarriage and stillbirth. A meta-analysis revealed a strong association of vitamin D deficiency/insufficiency with miscarriage. Another meta-analysis revealed that seafood and dairy products reduced the risk of miscarriage, whereas a caffeine intake of 300 mg/day or more was associated with miscarriage. A balanced diet that included nutrients with antioxidant properties helped prevent miscarriage, whereas a diet that included processed foods and nutrients with proinflammatory effects increased the risk of miscarriage. Associations of nutrients with RPL warrant further research.
J Nippon Med Sch 2024; 91: 254-260
Keywords
infertility, miscarriage, nutrient, review recurrent pregnancy loss
Correspondence to
Tomoko Ichikawa, MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
prima@nms.ac.jp
Received, December 26, 2023
Accepted, March 28, 2024
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