-Original-

Narrow Histopathological Margins are Acceptable in Surgical Resection of Basal Cell Carcinoma in Japanese: A Single-Center Retrospective Study

Shun Miyazaki¹, Toshihiko Hoashi¹, Yuki Tone¹, Aeri Park¹, Saki Otani¹, Naoko Kanda² and Hidehisa Saeki¹

¹Department of Dermatology, Nippon Medical School, Tokyo, Japan
²Department of Dermatology, Nippon Medical School, Chiba Hokusoh Hospital, Chiba, Japan

Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. BCCs occur mainly in exposed areas, such as the face and scalp. Therefore, surgical resection with narrow margins is highly desirable. However, narrow margins may increase the risk of positive histopathological margins. Outcomes for such treatment might be unfavorable, but evidence for such a conclusion is lacking.
Methods: Between April 2015 and November 2023, a total of 230 Japanese cases with BCC which underwent surgical resection with 2-mm, 3-mm, or 5-mm margins were followed in our hospital. We conducted a retrospective review that focused on the recurrence rate and histopathological margins.
Results: Recurrence was recorded if the follow-up time was longer than 3 months. One of the 198 cases (0.5%) developed a recurrence. The mean lateral and deep histopathological margins were 2,525.4 μm (30.8-14,034.6 μm) and 3,409 μm (199.9-16,523.6 μm), respectively. Recurrence rate was associated with tumor size and clinical tumor border. However, histopathological margin was not associated with recurrence rate, even when it was less than 1,000 μm.
Conclusions: A narrow histopathological margin is acceptable for surgical resection of BCC in Japanese patients.

J Nippon Med Sch 2024; 91: 296-306

Keywords
basal cell carcinoma, Japanese, recurrence, surgical margin, histopathological margin

Correspondence to
Toshihiko Hoashi, M.D., Ph.D., Department of Dermatology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
thoashi-tky@umin.ac.jp

Received, December 12, 2023
Accepted, January 5, 2024