|
-Case Reports-
A Rare Case of Extra-Nodal Rosai-Dorfman Disease of the Cheek
1Department of Plastic Surgery, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan
2Department of Dermatology, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan
Rosai-Dorfman disease (RDD), which was first reported by Rosai and Dorfman in 1969, is a rare, benign, non-neoplastic proliferation of histiocytes, characterized by painless lymphadenopathy and fever. Lymphadenopathy occurs most commonly in the neck, but also appears in non-cervical lymph nodes or as extranodal lesions. In this case, biopsy of an atypical subcutaneous buccal mass, which was difficult to diagnose preoperatively, led to a diagnosis of RDD. In addition, although lesions were also confirmed in the maxilla, none of the lesions were in lymph nodes; therefore, we ultimately diagnosed the patient with extranodal RDD (ENRDD). Compared with classical RDD, characterized by painless lymphadenopathy and fever, ENRDD is observed only in soft tissue and bone, and occurs mostly frequently among older adults. Cases presenting with lymph node or vital organ lesions also present with systemic symptoms, usually with a progressive and sometimes fatal course. However, RDD localized in soft tissue and bone has a favorable prognosis, and follow-up alone is considered sufficient. Although this case featured epidemiological characteristics of ENRDD, and as there are no fixed therapeutic guidelines, the recommendation is that treatment be considered on a case-by-case basis according to the site and symptoms. There are few reports of ENRDD; therefore, we aim to contribute the details of an additional case to the literature.
J Nippon Med Sch 2024; 91: 502-507
Keywords
Rosai-Dorfman disease, extra-nodal Rosai-Dorfman disease, soft tissue of Rosai-Dorfman disease, bone of Rosai-Dorfman disease, mesenchymal tumor
Correspondence to
Mami Shoji, Department of Plastic Surgery, Nippon Medical School Musashi Kosugi Hospital, 1-383 Kosugi-cho, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan
sjmm@nms.ac.jp
Received, February 16, 2023
Accepted, May 1, 2023