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-Case Reports-
Intravenous Unfractionated Heparin vs. Therapeutic Plasma Exchange in Patients with Autoimmune Disease with Acute Thrombotic Events: Sampling in a Case of Catastrophic Antiphospholipid Syndrome
1School of Medicine, China Medical University, Taichung City, Taiwan
2Division of Nephrology and Kidney Institute, Department of Internal Medicine, China Medical University Hospital, Taichung City, Taiwan
A variety of autoimmune disorders are associated with an increased risk of thrombosis. Previous studies have suggested combined therapy of heparin and therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) as the replacement fluid is beneficial in some cases of acute flare-up of autoimmune diseases complicated by thrombotic events. Nevertheless, it remains unknown whether clinicians do more harm than good by exposing patients to a "thrombotic storm" through simultaneous administration of heparin and the clotting factors in the FFP during TPE. A variety of data are currently available on therapeutic interventions for autoimmune diseases complicated with acute thrombosis; however, there is limited evidence on the exact efficacy of each individual approach and combinations of these measures. Herein, we report a case of catastrophic antiphospholipid syndrome (CAPS) to highlight the difficulty of therapeutic decision-making when complicated interactions occur between heparin and TPE. To our knowledge, this is the first case report of a patient diagnosed with CAPS successfully treated with a novel therapeutic strategy of escalating the heparin dosage when performing TPE by monitoring the partial prothrombin time to reduce the risk of the progression of thrombosis.
J Nippon Med Sch 2024; 91: 548-553
Keywords
plasma exchange, heparin, thrombosis, antiphospholipid syndrome
Correspondence to
Jiung-Hsiun Liu, Division of Nephrology and Kidney Institute, Department of Internal Medicine, China Medical University Hospital, 2 Yuh-Der Road, Taichung City 404, Taiwan
d36853@mail.cmuh.org.tw
Received, March 18, 2023
Accepted, June 23, 2023