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ArticleTitle | Fibroin allergy IgE mediated hypersensitivity to silk suture materials |
AuthorList | Sadayuki Kurosaki 1) , Hirokuni Otsuka 1) , Mayumi Kunitomo 1) , Mamoru Koyama 1) , Ruby Pawankar 1) and Koshi Matumoto 2) |
Affiliation | 1) Department of Otolaryngology, Nippon Medical School 2) Department of Pathology, Nippon Medical School |
Language | EN |
Volume | 66 |
Issue | 1 |
Year | 1999 |
Page | 41-44 |
Received | November 11, 1998 |
Accepted | December 4, 1998 |
Keywords | silk suture, fibroin, type I allergy, IgE-mediated hypersensitivity, granuloma |
Abstract | Delayed-type hypersensitivity with granulomatous lesions to silk sutures is rather rare. Yet, braided silk sutures often act as a non-immunologic foreign-body and cause a granulomatous inflammatory reaction years after surgery. We report here a case of recurrent granulomas with remarkable infiltration of eosinophils that may have resulted from an IgE-mediated hypersensitivity reaction to silk fibroin, a component of the braided silk suture. Under normal circumstances exposure to fibroin is rather rare. Therefore, the present patient may have developed this reaction to the silk sutures used in a previous surgery. |
Correspondence to | Sadayuki Kurosaki, Department of Otolaryngology, Nippon Modical School Second Hospital, 1-396 Kosugicho, Nakahara-ku Kawasaki Kanagawa 211-8533, Japan |
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