Journal of Nippon Medical School: Vol.66 No.1 page.041

Journal of Nippon Medical School

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ArticleTitle Fibroin allergy IgE mediated hypersensitivity to silk suture materials

AuthorList Sadayuki Kurosaki¹⁾ , Hirokuni Otsuka¹⁾ , Mayumi Kunitomo¹⁾ , Mamoru Koyama¹⁾ , Ruby Pawankar¹⁾ and Koshi Matumoto²⁾

Affiliation ¹⁾ Department of Otolaryngology, Nippon Medical School²⁾ Department of Pathology, Nippon Medical School

Language EN

Volume 66

Issue 1

Year 1999

Page 41-44

Received November 11, 1998

Accepted December 4, 1998

Keywords silk suture, fibroin, type I allergy, IgE-mediated hypersensitivity, granuloma

Abstract Delayed-type hypersensitivity with granulomatous lesions to silk sutures is rather rare. Yet, braided silk sutures often act as a non-immunologic foreign-body and cause a granulomatous inflammatory reaction years after surgery. We report here a case of recurrent granulomas with remarkable infiltration of eosinophils that may have resulted from an IgE-mediated hypersensitivity reaction to silk fibroin, a component of the braided silk suture. Under normal circumstances exposure to fibroin is rather rare. Therefore, the present patient may have developed this reaction to the silk sutures used in a previous surgery.

Correspondence to Sadayuki Kurosaki, Department of Otolaryngology, Nippon Modical School Second Hospital, 1-396 Kosugicho, Nakahara-ku Kawasaki Kanagawa 211-8533, Japan

ArticleTitle	Fibroin allergy IgE mediated hypersensitivity to silk suture materials
AuthorList	Sadayuki Kurosaki¹⁾ , Hirokuni Otsuka¹⁾ , Mayumi Kunitomo¹⁾ , Mamoru Koyama¹⁾ , Ruby Pawankar¹⁾ and Koshi Matumoto²⁾
Affiliation	¹⁾ Department of Otolaryngology, Nippon Medical School²⁾ Department of Pathology, Nippon Medical School
Language	EN
Volume	66
Issue	1
Year	1999
Page	41-44
Received	November 11, 1998
Accepted	December 4, 1998
Keywords	silk suture, fibroin, type I allergy, IgE-mediated hypersensitivity, granuloma
Abstract	Delayed-type hypersensitivity with granulomatous lesions to silk sutures is rather rare. Yet, braided silk sutures often act as a non-immunologic foreign-body and cause a granulomatous inflammatory reaction years after surgery. We report here a case of recurrent granulomas with remarkable infiltration of eosinophils that may have resulted from an IgE-mediated hypersensitivity reaction to silk fibroin, a component of the braided silk suture. Under normal circumstances exposure to fibroin is rather rare. Therefore, the present patient may have developed this reaction to the silk sutures used in a previous surgery.
Correspondence to	Sadayuki Kurosaki, Department of Otolaryngology, Nippon Modical School Second Hospital, 1-396 Kosugicho, Nakahara-ku Kawasaki Kanagawa 211-8533, Japan