Journal of Nippon Medical School: Vol.66 No.6 page.382

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ArticleTitle The short-term effects of tamsulosin in Japanese men with benign prostatic hyperplasia

AuthorList Kazutaka Horiuchi, Narumi Tsuboi, Tomotaka Hattori, Kazuhiro Yoshida and Masao Akimoto

Affiliation Department of Urology, Nippon Medical School

Language EN

Volume 66

Issue 6

Year 1999

Page 382-387

Received July15,1999

Accepted September16,1999

Keywords prostate, benign prostatic hyperplasia, clinical effect, tamsulosin

Abstract We evaluated the short-term effects of tamsulosin in treating benign prostatic hyperplasia. Twenty-seven patients, aged57to86years(mean68.4), complaining of obstructive urinary symptoms who had received no previous treatment for such symptoms were orally administered0.2mg of tamsulosin for4weeks. Symptoms(total AUA symptom score and AUA symptom subscores)and objective parameters including peak and average flow rate, and post-void residual urine rate were evaluated before and after1,2and4weeks of treatment. The mean total AUA symptom score and the mean AUA symptom subscores for incomplete emptying and weak stream were significantly decreased after only1week of treatment. The mean AUA symptom subscores for intermittency, urgency and nocturia were significantly decreased after4weeks of treatment. The mean AUA symptom subscores for frequency and hesitancy were unchanged after4weeks of treatment. The mean peak and average flow rate, and post-void residual urine rate were significantly improved after only1week of treatment. In conclusion, tamsulosin improved not only objective parameters but also symptoms only1week after the start of treatment.

Correspondence to Kazutaka Horiuchi, Department of Urology, Nippon Medical School,1-1-5Sendagi, Bunkyo-ku, Tokyo113-8603, Japan

ArticleTitle	The short-term effects of tamsulosin in Japanese men with benign prostatic hyperplasia
AuthorList	Kazutaka Horiuchi, Narumi Tsuboi, Tomotaka Hattori, Kazuhiro Yoshida and Masao Akimoto
Affiliation	Department of Urology, Nippon Medical School
Language	EN
Volume	66
Issue	6
Year	1999
Page	382-387
Received	July15,1999
Accepted	September16,1999
Keywords	prostate, benign prostatic hyperplasia, clinical effect, tamsulosin
Abstract	We evaluated the short-term effects of tamsulosin in treating benign prostatic hyperplasia. Twenty-seven patients, aged57to86years(mean68.4), complaining of obstructive urinary symptoms who had received no previous treatment for such symptoms were orally administered0.2mg of tamsulosin for4weeks. Symptoms(total AUA symptom score and AUA symptom subscores)and objective parameters including peak and average flow rate, and post-void residual urine rate were evaluated before and after1,2and4weeks of treatment. The mean total AUA symptom score and the mean AUA symptom subscores for incomplete emptying and weak stream were significantly decreased after only1week of treatment. The mean AUA symptom subscores for intermittency, urgency and nocturia were significantly decreased after4weeks of treatment. The mean AUA symptom subscores for frequency and hesitancy were unchanged after4weeks of treatment. The mean peak and average flow rate, and post-void residual urine rate were significantly improved after only1week of treatment. In conclusion, tamsulosin improved not only objective parameters but also symptoms only1week after the start of treatment.
Correspondence to	Kazutaka Horiuchi, Department of Urology, Nippon Medical School,1-1-5Sendagi, Bunkyo-ku, Tokyo113-8603, Japan