Journal of Nippon Medical School: Vol.67 No.4 page.250

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ArticleTitle Morphometrical Analysis of the Relationship between Helicobacter Pylori Infection and Pathological Changes of Gastric Mucosa Using Sano's 4 Point Biopsy Method

AuthorList Akira Toyoshima, Masahide Ito and Yukichi Moriyama

Affiliation Center for Digestive Diseases, Nippon Medical School Second Hospital

Language JA

Volume 67

Issue 4

Year 2000

Page 250-260

Received September 28, 1999

Accepted June 18, 2000

Keywords Helicobacter Pylori, treatment of Helicobacter Pylori infectio n, biopsies at Sano's 4 points, gastric mucosal atrophy, inflammatory change of gastric mucosa

Abstract We examined Helicobacter Pylori (H. p. ) infection and changes in biopsied gastric mucosa as observed in biopsy specimens (inflammatory changes and atrophic changes) -with reference to their pathophysiological significance. We examined 68 patients with peptic ulcers and 19 patients with atrophic gastritis as controls. We confirmed H. p. infection of the gastric mucosa in biopsies from two points by tissue culture, microscopy and urease testing. We examined gastric mucosal flakes under microscopy, scoring the inflammatory changes and atrophic changes, from biopsies at Sano's 4 points. We compared the gastric mucosal condition of the H. p. (+) group and that of the H. p. (-) group histopathologically. The mucosal condition of the success fully treated H. p. infection group and that of the failure group were also investigated in the same way, as were the conditions before and after treatment. Results: 1) The gastric mucosal inflammatory changes in the H. p. (+) group were more severe than those in the H. p. (-) group at all 4 biopsy points. 2) The gastric mucosal atrophy of the H. p. (+) group was more severe than that of the H. p. (-) group at all 4 biopsy points. 3) The gastric mucosal inflammatory changes in the treatment failure group were more severe than those in the Successful treatment group at all 4 biopsy points. 4) The gastric mucosal atrophy of the treatment failure group was more severe than that of the successful, treatment group at the anterior wall and the posterior wall of the body of the stomach. 5) The gastric mucosal inflammatory changes before treatment were more severe than those after treatment at all 4 biopsy points. 6) The gastric mucosal atrophy before treatment was more severe than that after treatment at the antrum and the angle of the stomach. Discussion: H. p. infection seemed to cause changes in mucosal condition, severity of gastric mucosal inflammation and gastric mucosal atrophy at all 4 of Sano's points.

Correspondence to Akira Toyoshima, Center for Digestive Diseases, Nippon Medical School Second Hospital, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki-shi, Kanagawa-ken 211-8533, Japan

ArticleTitle	Morphometrical Analysis of the Relationship between Helicobacter Pylori Infection and Pathological Changes of Gastric Mucosa Using Sano's 4 Point Biopsy Method
AuthorList	Akira Toyoshima, Masahide Ito and Yukichi Moriyama
Affiliation	Center for Digestive Diseases, Nippon Medical School Second Hospital
Language	JA
Volume	67
Issue	4
Year	2000
Page	250-260
Received	September 28, 1999
Accepted	June 18, 2000
Keywords	Helicobacter Pylori, treatment of Helicobacter Pylori infectio n, biopsies at Sano's 4 points, gastric mucosal atrophy, inflammatory change of gastric mucosa
Abstract	We examined Helicobacter Pylori (H. p. ) infection and changes in biopsied gastric mucosa as observed in biopsy specimens (inflammatory changes and atrophic changes) -with reference to their pathophysiological significance. We examined 68 patients with peptic ulcers and 19 patients with atrophic gastritis as controls. We confirmed H. p. infection of the gastric mucosa in biopsies from two points by tissue culture, microscopy and urease testing. We examined gastric mucosal flakes under microscopy, scoring the inflammatory changes and atrophic changes, from biopsies at Sano's 4 points. We compared the gastric mucosal condition of the H. p. (+) group and that of the H. p. (-) group histopathologically. The mucosal condition of the success fully treated H. p. infection group and that of the failure group were also investigated in the same way, as were the conditions before and after treatment. Results: 1) The gastric mucosal inflammatory changes in the H. p. (+) group were more severe than those in the H. p. (-) group at all 4 biopsy points. 2) The gastric mucosal atrophy of the H. p. (+) group was more severe than that of the H. p. (-) group at all 4 biopsy points. 3) The gastric mucosal inflammatory changes in the treatment failure group were more severe than those in the Successful treatment group at all 4 biopsy points. 4) The gastric mucosal atrophy of the treatment failure group was more severe than that of the successful, treatment group at the anterior wall and the posterior wall of the body of the stomach. 5) The gastric mucosal inflammatory changes before treatment were more severe than those after treatment at all 4 biopsy points. 6) The gastric mucosal atrophy before treatment was more severe than that after treatment at the antrum and the angle of the stomach. Discussion: H. p. infection seemed to cause changes in mucosal condition, severity of gastric mucosal inflammation and gastric mucosal atrophy at all 4 of Sano's points.
Correspondence to	Akira Toyoshima, Center for Digestive Diseases, Nippon Medical School Second Hospital, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki-shi, Kanagawa-ken 211-8533, Japan