Journal of Nippon Medical School: Vol.67 No.4 page.261

Journal of Nippon Medical School

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ArticleTitle Effects of SSM (Specific Substance Maruyama) on HBe Antigen-Positive Chronic Hepatitis B -Clinical Efficacy and Modulation of Cytokines-

AuthorList Katsuaki Satomura¹, Mingshi Yin², Tatsuya Sekiyama¹, Shigeko Fujisaki¹, Takumi Aramaki¹, Hidemasa Okumura³ and Yasukazu Ohmoto⁴

Affiliation ¹The First Department of Internal Medicine, Nippon Medical School ²Department of Infectious Diseases, Yan bian Medical School, China ³Professor Emeritus of Nippon Medical School ⁴First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.

Language EN

Volume 67

Issue 4

Year 2000

Page 261-266

Received March 27, 2000

Accepted May 18, 2000

Keywords SSM (special substance Maruyama), HBeAg positive chronic hepatitis B, cytokine, interleukin-10. interferon-γ

Abstract Twenty-three patients with HBe antigen-positive chronic hepatitis B were treated with capitalite first letters Maruyama (SSM). HBe antigen turned negative in 15 patients. The levels of various cytokines in pre- and post-treatment frozen serum samples from six patients whose HBe antigen turned negative and from five whose HBe antigen did not were examined. Reduction of serum interleukin (IL) -10 level to below 20 pg/ml was observed after SSM treatment in four of the six patients whose HBe antigen turned negative. SSM was found to stimulate the production of interferon (IFN) -γ in peripheral blood cells from two healthy volunteers. This stimulatory effect was confirmed in 12 out of 24 healthy volunteers. SSM augmented the production of IFN-γ in eight out of 10 patients with chronic hepatitis B and nine of 10 with hepatitis C. These results demonstrate for the first time that SSM stimulates the production of IFN-γ in human peripheral blood cells and also suggest that treatment of HBe antigen-positive chronic hepatitis B patients with SSM leads to the clearance of HBe antigen and normalization of serum aspartate aminotransferase levels through inhibition of IL-10 and stimulation of IFN-γ (J Nippon Med Sch 2000; 67: 261-266)

Correspondence to Katsuaki Satomura, M. D. , The First Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku Tokyo, 113-8603 Japan. Phone: +81-3-3822-2131, Fax: +81-3-5685-0987

ArticleTitle	Effects of SSM (Specific Substance Maruyama) on HBe Antigen-Positive Chronic Hepatitis B -Clinical Efficacy and Modulation of Cytokines-
AuthorList	Katsuaki Satomura¹, Mingshi Yin², Tatsuya Sekiyama¹, Shigeko Fujisaki¹, Takumi Aramaki¹, Hidemasa Okumura³ and Yasukazu Ohmoto⁴
Affiliation	¹The First Department of Internal Medicine, Nippon Medical School ²Department of Infectious Diseases, Yan bian Medical School, China ³Professor Emeritus of Nippon Medical School ⁴First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.
Language	EN
Volume	67
Issue	4
Year	2000
Page	261-266
Received	March 27, 2000
Accepted	May 18, 2000
Keywords	SSM (special substance Maruyama), HBeAg positive chronic hepatitis B, cytokine, interleukin-10. interferon-γ
Abstract	Twenty-three patients with HBe antigen-positive chronic hepatitis B were treated with capitalite first letters Maruyama (SSM). HBe antigen turned negative in 15 patients. The levels of various cytokines in pre- and post-treatment frozen serum samples from six patients whose HBe antigen turned negative and from five whose HBe antigen did not were examined. Reduction of serum interleukin (IL) -10 level to below 20 pg/ml was observed after SSM treatment in four of the six patients whose HBe antigen turned negative. SSM was found to stimulate the production of interferon (IFN) -γ in peripheral blood cells from two healthy volunteers. This stimulatory effect was confirmed in 12 out of 24 healthy volunteers. SSM augmented the production of IFN-γ in eight out of 10 patients with chronic hepatitis B and nine of 10 with hepatitis C. These results demonstrate for the first time that SSM stimulates the production of IFN-γ in human peripheral blood cells and also suggest that treatment of HBe antigen-positive chronic hepatitis B patients with SSM leads to the clearance of HBe antigen and normalization of serum aspartate aminotransferase levels through inhibition of IL-10 and stimulation of IFN-γ (J Nippon Med Sch 2000; 67: 261-266)
Correspondence to	Katsuaki Satomura, M. D. , The First Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku Tokyo, 113-8603 Japan. Phone: +81-3-3822-2131, Fax: +81-3-5685-0987