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ArticleTitle | Effects of SSM (Specific Substance Maruyama) on HBe Antigen-Positive Chronic Hepatitis B -Clinical Efficacy and Modulation of Cytokines- |
AuthorList | Katsuaki Satomura1, Mingshi Yin2, Tatsuya Sekiyama1, Shigeko Fujisaki1, Takumi Aramaki1, Hidemasa Okumura3 and Yasukazu Ohmoto4 |
Affiliation | 1The First Department of Internal Medicine, Nippon Medical School 2Department of Infectious Diseases, Yan bian Medical School, China 3Professor Emeritus of Nippon Medical School 4First Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd. |
Language | EN |
Volume | 67 |
Issue | 4 |
Year | 2000 |
Page | 261-266 |
Received | March 27, 2000 |
Accepted | May 18, 2000 |
Keywords | SSM (special substance Maruyama), HBeAg positive chronic hepatitis B, cytokine, interleukin-10. interferon-γ |
Abstract | Twenty-three patients with HBe antigen-positive chronic hepatitis B were treated with capitalite first letters Maruyama (SSM). HBe antigen turned negative in 15 patients. The levels of various cytokines in pre- and post-treatment frozen serum samples from six patients whose HBe antigen turned negative and from five whose HBe antigen did not were examined. Reduction of serum interleukin (IL) -10 level to below 20 pg/ml was observed after SSM treatment in four of the six patients whose HBe antigen turned negative. SSM was found to stimulate the production of interferon (IFN) -γ in peripheral blood cells from two healthy volunteers. This stimulatory effect was confirmed in 12 out of 24 healthy volunteers. SSM augmented the production of IFN-γ in eight out of 10 patients with chronic hepatitis B and nine of 10 with hepatitis C. These results demonstrate for the first time that SSM stimulates the production of IFN-γ in human peripheral blood cells and also suggest that treatment of HBe antigen-positive chronic hepatitis B patients with SSM leads to the clearance of HBe antigen and normalization of serum aspartate aminotransferase levels through inhibition of IL-10 and stimulation of IFN-γ (J Nippon Med Sch 2000; 67: 261-266) |
Correspondence to | Katsuaki Satomura, M. D. , The First Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku Tokyo, 113-8603 Japan. Phone: +81-3-3822-2131, Fax: +81-3-5685-0987 |
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