Journal of Nippon Medical School: Vol.67 No.6 page.459

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ArticleTitle Transient Osteoporosis of the Hip During Pregnancy

AuthorList Naoko Uematsu, Yoshihito Nakayama, Yasumasa Shirai, Kensuke Tamai, Hiroshi Hashiguchi and Yuko Banzai

Affiliation Department of Orthopaedic Surgery, Nippon Medical School

Language EN

Volume 67

Issue 6

Year 2000

Page 459-463

Received June 6, 2000

Accepted June 14, 2000

Keywords transient osteoporosis, pregnancy, bone marrow edema, hip

Abstract We report the clinical features of and MRI findings in transient osteoporosis of the hip during pregnancy. The study population consisted of 4 patients with a mean age of 33 years. The mean gestational age at onset was 31 weeks (range: 27 to 35 weeks). The main symptoms consisted of a weight-bearing pain in the hip and gait disturbance. The pain occured suddenly and was of unknown cause and became severe within 2 to 3 weeks. X-ray examinations showed diffuse osteoporosis in the femoral head and neck. Moreover in 3 patients, similar lesions were also found in the lumbar spine or the knee. MRI obtained from 3 patients revealed a mottled low-signal lesion extending from the femoral head and neck on T1-weighted images and a high-signal lesion in the bone marrow suggesting edema on T2-weighted images. Mild elevation of C- reactive protein was shown in 2 patients. Conservative treatments with the limitation of weight bearing and bed rest were performed for all patients, and nonsteroidal anti-inflammatory drugs were given to 3 patients. The hip pain began to decline from 8 to 14 weeks after the onset, and completely disappeared from 14 to 24 weeks. X-ray examinations showed that osteoporotic lesions tended to improve at 10 to 14 weeks, on MRI, a high-signal lesion suggesting bone marrow edema resolved together with relief of the pain. No recurrence was found in any patients at mean follow-up of 70.8 months.

Correspondence to Naoko Uematsu, M.D., Department of Orthopaedic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan
naoko-u@f2.dion.ne.jp

ArticleTitle	Transient Osteoporosis of the Hip During Pregnancy
AuthorList	Naoko Uematsu, Yoshihito Nakayama, Yasumasa Shirai, Kensuke Tamai, Hiroshi Hashiguchi and Yuko Banzai
Affiliation	Department of Orthopaedic Surgery, Nippon Medical School
Language	EN
Volume	67
Issue	6
Year	2000
Page	459-463
Received	June 6, 2000
Accepted	June 14, 2000
Keywords	transient osteoporosis, pregnancy, bone marrow edema, hip
Abstract	We report the clinical features of and MRI findings in transient osteoporosis of the hip during pregnancy. The study population consisted of 4 patients with a mean age of 33 years. The mean gestational age at onset was 31 weeks (range: 27 to 35 weeks). The main symptoms consisted of a weight-bearing pain in the hip and gait disturbance. The pain occured suddenly and was of unknown cause and became severe within 2 to 3 weeks. X-ray examinations showed diffuse osteoporosis in the femoral head and neck. Moreover in 3 patients, similar lesions were also found in the lumbar spine or the knee. MRI obtained from 3 patients revealed a mottled low-signal lesion extending from the femoral head and neck on T1-weighted images and a high-signal lesion in the bone marrow suggesting edema on T2-weighted images. Mild elevation of C- reactive protein was shown in 2 patients. Conservative treatments with the limitation of weight bearing and bed rest were performed for all patients, and nonsteroidal anti-inflammatory drugs were given to 3 patients. The hip pain began to decline from 8 to 14 weeks after the onset, and completely disappeared from 14 to 24 weeks. X-ray examinations showed that osteoporotic lesions tended to improve at 10 to 14 weeks, on MRI, a high-signal lesion suggesting bone marrow edema resolved together with relief of the pain. No recurrence was found in any patients at mean follow-up of 70.8 months.
Correspondence to	Naoko Uematsu, M.D., Department of Orthopaedic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan naoko-u@f2.dion.ne.jp