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ArticleTitle | Transient Osteoporosis of the Hip During Pregnancy |
AuthorList | Naoko Uematsu, Yoshihito Nakayama, Yasumasa Shirai, Kensuke Tamai, Hiroshi Hashiguchi and Yuko Banzai |
Affiliation | Department of Orthopaedic Surgery, Nippon Medical School |
Language | EN |
Volume | 67 |
Issue | 6 |
Year | 2000 |
Page | 459-463 |
Received | June 6, 2000 |
Accepted | June 14, 2000 |
Keywords | transient osteoporosis, pregnancy, bone marrow edema, hip |
Abstract | We report the clinical features of and MRI findings in transient osteoporosis of the hip during pregnancy. The study population consisted of 4 patients with a mean age of 33 years. The mean gestational age at onset was 31 weeks (range: 27 to 35 weeks). The main symptoms consisted of a weight-bearing pain in the hip and gait disturbance. The pain occured suddenly and was of unknown cause and became severe within 2 to 3 weeks. X-ray examinations showed diffuse osteoporosis in the femoral head and neck. Moreover in 3 patients, similar lesions were also found in the lumbar spine or the knee. MRI obtained from 3 patients revealed a mottled low-signal lesion extending from the femoral head and neck on T1-weighted images and a high-signal lesion in the bone marrow suggesting edema on T2-weighted images. Mild elevation of C- reactive protein was shown in 2 patients. Conservative treatments with the limitation of weight bearing and bed rest were performed for all patients, and nonsteroidal anti-inflammatory drugs were given to 3 patients. The hip pain began to decline from 8 to 14 weeks after the onset, and completely disappeared from 14 to 24 weeks. X-ray examinations showed that osteoporotic lesions tended to improve at 10 to 14 weeks, on MRI, a high-signal lesion suggesting bone marrow edema resolved together with relief of the pain. No recurrence was found in any patients at mean follow-up of 70.8 months. |
Correspondence to | Naoko Uematsu, M.D., Department of Orthopaedic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan naoko-u@f2.dion.ne.jp |
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