Journal of Nippon Medical School: Vol.70 No.2 page.151

Journal of Nippon Medical School

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ArticleTitle Fetal Plasma Prostaglandin F_2α and Cortisol Responses to High-Dose Endotoxin Administration in Fetal Goats

AuthorList Atsushi Miura, Yoshio Yoneyama, Rintaro Sawa and Tsutomu Araki

Affiliation Department of Obstetrics and Gynecology, Nippon Medical School

Language EN

Volume 70

Issue 2

Year 2003

Page 151-156

Received October 7, 2002

Accepted November 15, 2002

Keywords fetus, endotoxin, prostaglandin F_2α, cortisol

Abstract Intrauterine inflammation/infection has been associated with prenatal mortality and morbidity. However, few studies have been performed to investigate how the fetus responds to intrauterine inflammation/infection in utero. In the present study, fetal plasma prostaglandin (PG) F_2α and cortisol responses to high-dose fetal endotoxin administration were evaluated in late gestation goats (n=8). After 160μg/kg of fetal weight of endotoxin (Escherichia coli, O111:B4 lipopolysaccharide) administration via the fetal jugular vein over a 5-min period, fetal plasma PGF_2α and cortisol levels, fetal blood gases and pH were measured periodically.
After endotoxin administration, fetal plasma cortisol levels significantly increased to 9.5±0.8 ng/mL and 9.3±0.7 ng/mL after 1 and 3h, respectively (p<0.05) and plasma PGF_2α levels did not change throughout the study. These results suggest that absent PGF_2α and attenuated cortisol responses to high-dose fetal endotoxin administration, relative to the adult, may be a self-protective mechanism that diminishes premature delivery and fetal asphyxia.

Correspondence to Yoshio Yoneyama, MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
yoshi-1@nms.ac.jp

ArticleTitle	Fetal Plasma Prostaglandin F_2α and Cortisol Responses to High-Dose Endotoxin Administration in Fetal Goats
AuthorList	Atsushi Miura, Yoshio Yoneyama, Rintaro Sawa and Tsutomu Araki
Affiliation	Department of Obstetrics and Gynecology, Nippon Medical School
Language	EN
Volume	70
Issue	2
Year	2003
Page	151-156
Received	October 7, 2002
Accepted	November 15, 2002
Keywords	fetus, endotoxin, prostaglandin F_2α, cortisol
Abstract	Intrauterine inflammation/infection has been associated with prenatal mortality and morbidity. However, few studies have been performed to investigate how the fetus responds to intrauterine inflammation/infection in utero. In the present study, fetal plasma prostaglandin (PG) F_2α and cortisol responses to high-dose fetal endotoxin administration were evaluated in late gestation goats (n=8). After 160μg/kg of fetal weight of endotoxin (Escherichia coli, O111:B4 lipopolysaccharide) administration via the fetal jugular vein over a 5-min period, fetal plasma PGF_2α and cortisol levels, fetal blood gases and pH were measured periodically. After endotoxin administration, fetal plasma cortisol levels significantly increased to 9.5±0.8 ng/mL and 9.3±0.7 ng/mL after 1 and 3h, respectively (p<0.05) and plasma PGF_2α levels did not change throughout the study. These results suggest that absent PGF_2α and attenuated cortisol responses to high-dose fetal endotoxin administration, relative to the adult, may be a self-protective mechanism that diminishes premature delivery and fetal asphyxia.
Correspondence to	Yoshio Yoneyama, MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan yoshi-1@nms.ac.jp