Home > List of Issue > Table of Contents > Abstract
![]() |
![]() |
|||||
Select Language in Japanese < > in English |
|
ArticleTitle | Fetal Plasma Prostaglandin F2α and Cortisol Responses to High-Dose Endotoxin Administration in Fetal Goats |
AuthorList | Atsushi Miura, Yoshio Yoneyama, Rintaro Sawa and Tsutomu Araki |
Affiliation | Department of Obstetrics and Gynecology, Nippon Medical School |
Language | EN |
Volume | 70 |
Issue | 2 |
Year | 2003 |
Page | 151-156 |
Received | October 7, 2002 |
Accepted | November 15, 2002 |
Keywords | fetus, endotoxin, prostaglandin F2α, cortisol |
Abstract | Intrauterine inflammation/infection has been associated with prenatal mortality and morbidity. However, few studies have been performed to investigate how the fetus responds to intrauterine inflammation/infection in utero. In the present study, fetal plasma prostaglandin (PG) F2α and cortisol responses to high-dose fetal endotoxin administration were evaluated in late gestation goats (n=8). After 160μg/kg of fetal weight of endotoxin (Escherichia coli, O111:B4 lipopolysaccharide) administration via the fetal jugular vein over a 5-min period, fetal plasma PGF2α and cortisol levels, fetal blood gases and pH were measured periodically. After endotoxin administration, fetal plasma cortisol levels significantly increased to 9.5±0.8 ng/mL and 9.3±0.7 ng/mL after 1 and 3h, respectively (p<0.05) and plasma PGF2α levels did not change throughout the study. These results suggest that absent PGF2α and attenuated cortisol responses to high-dose fetal endotoxin administration, relative to the adult, may be a self-protective mechanism that diminishes premature delivery and fetal asphyxia. |
Correspondence to | Yoshio Yoneyama, MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan yoshi-1@nms.ac.jp |
Copyright © The Medical Association of Nippon Medical School