Home > List of Issue > Table of Contents > Abstract

Journal of Nippon Medical School
Select Language
in Japanese < > in English

Full Text of this Article
in English PDF (304K)

ArticleTitle Expression of p73 and c-Abl Proteins in Human Ovarian Carcinomas
AuthorList Maynur Niyazi1, 2, Mohammad Ghazizadeh2, Hideki Konishi1, Oichi Kawanami2, Yuichi Sugisaki3 and Tsutomu Araki1
Affiliation 1The Department of Obstetrics and Gynecology, Nippon Medical School
2Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
3Division of Surgical Pathology, Nippon Medical School
Language EN
Volume 70
Issue 3
Year 2003
Page 234-242
Received December 5, 2002
Accepted December 27, 2002
Keywords ovarian tumor, p73, c-Abl, immunohistochemistry, disease stage, survival
Abstract The p73, a homologue of the p53 tumor suppressor protein, has a pro-apoptotic activity which is induced by the c-Abl, a protein tyrosine kinase appearing in the nucleus and cytoplasm of proliferating cells. However, the role of p73 and c-Abl in ovarian cancer is not well-defined. We investigated immunohistochemical expressions of p73 and c-Abl in 64 ovarian carcinomas, 13 borderline and 14 benign ovarian tumors to elucidate their clinicopathological relevances. Of the malignant, borderline, and benign ovarian tumors, respectively, 33 (51%), 10 (77%) and 13 (93%) had negative or low p73 expression, 31 (48%), 3 (23%) and 1 (7%) had high p73 expression, 23 (36%), 5 (38%) and 10 (71%) had negative or low c-Abl expression, and 41 (64%), 8 (61%) and 4 (29%) had high c-Abl expression. A high p73 or c-Abl expression was significantly associated with ovarian carcinomas as compared to benign tumors (p=0.003 and p=0.03 respectively). In addition, a significant correlation was found between the high p73 expression and disease stage (p=0.04) and patient's survival (p=0.02). No correlation was found with c-Abl expression. These results reveal an association of p73 overexpression with advanced ovarian carcinomas which may suggest the p73 overexpression as an indicator of poor prognosis.
Correspondence to Mohammad Ghazizadeh, MD, Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku Kawasaki, Kanagawa 211-8533 Japan
ciem@nms.ac.jp

Copyright © The Medical Association of Nippon Medical School