Journal of Nippon Medical School: Vol.70 No.3 page.234

Journal of Nippon Medical School

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ArticleTitle Expression of p73 and c-Abl Proteins in Human Ovarian Carcinomas

AuthorList Maynur Niyazi^{1, 2}, Mohammad Ghazizadeh², Hideki Konishi¹, Oichi Kawanami², Yuichi Sugisaki³ and Tsutomu Araki¹

Affiliation ¹The Department of Obstetrics and Gynecology, Nippon Medical School
²Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
³Division of Surgical Pathology, Nippon Medical School

Language EN

Volume 70

Issue 3

Year 2003

Page 234-242

Received December 5, 2002

Accepted December 27, 2002

Keywords ovarian tumor, p73, c-Abl, immunohistochemistry, disease stage, survival

Abstract The p73, a homologue of the p53 tumor suppressor protein, has a pro-apoptotic activity which is induced by the c-Abl, a protein tyrosine kinase appearing in the nucleus and cytoplasm of proliferating cells. However, the role of p73 and c-Abl in ovarian cancer is not well-defined. We investigated immunohistochemical expressions of p73 and c-Abl in 64 ovarian carcinomas, 13 borderline and 14 benign ovarian tumors to elucidate their clinicopathological relevances. Of the malignant, borderline, and benign ovarian tumors, respectively, 33 (51%), 10 (77%) and 13 (93%) had negative or low p73 expression, 31 (48%), 3 (23%) and 1 (7%) had high p73 expression, 23 (36%), 5 (38%) and 10 (71%) had negative or low c-Abl expression, and 41 (64%), 8 (61%) and 4 (29%) had high c-Abl expression. A high p73 or c-Abl expression was significantly associated with ovarian carcinomas as compared to benign tumors (p=0.003 and p=0.03 respectively). In addition, a significant correlation was found between the high p73 expression and disease stage (p=0.04) and patient's survival (p=0.02). No correlation was found with c-Abl expression. These results reveal an association of p73 overexpression with advanced ovarian carcinomas which may suggest the p73 overexpression as an indicator of poor prognosis.

Correspondence to Mohammad Ghazizadeh, MD, Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku Kawasaki, Kanagawa 211-8533 Japan
ciem@nms.ac.jp

ArticleTitle	Expression of p73 and c-Abl Proteins in Human Ovarian Carcinomas
AuthorList	Maynur Niyazi^{1, 2}, Mohammad Ghazizadeh², Hideki Konishi¹, Oichi Kawanami², Yuichi Sugisaki³ and Tsutomu Araki¹
Affiliation	¹The Department of Obstetrics and Gynecology, Nippon Medical School ²Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School ³Division of Surgical Pathology, Nippon Medical School
Language	EN
Volume	70
Issue	3
Year	2003
Page	234-242
Received	December 5, 2002
Accepted	December 27, 2002
Keywords	ovarian tumor, p73, c-Abl, immunohistochemistry, disease stage, survival
Abstract	The p73, a homologue of the p53 tumor suppressor protein, has a pro-apoptotic activity which is induced by the c-Abl, a protein tyrosine kinase appearing in the nucleus and cytoplasm of proliferating cells. However, the role of p73 and c-Abl in ovarian cancer is not well-defined. We investigated immunohistochemical expressions of p73 and c-Abl in 64 ovarian carcinomas, 13 borderline and 14 benign ovarian tumors to elucidate their clinicopathological relevances. Of the malignant, borderline, and benign ovarian tumors, respectively, 33 (51%), 10 (77%) and 13 (93%) had negative or low p73 expression, 31 (48%), 3 (23%) and 1 (7%) had high p73 expression, 23 (36%), 5 (38%) and 10 (71%) had negative or low c-Abl expression, and 41 (64%), 8 (61%) and 4 (29%) had high c-Abl expression. A high p73 or c-Abl expression was significantly associated with ovarian carcinomas as compared to benign tumors (p=0.003 and p=0.03 respectively). In addition, a significant correlation was found between the high p73 expression and disease stage (p=0.04) and patient's survival (p=0.02). No correlation was found with c-Abl expression. These results reveal an association of p73 overexpression with advanced ovarian carcinomas which may suggest the p73 overexpression as an indicator of poor prognosis.
Correspondence to	Mohammad Ghazizadeh, MD, Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku Kawasaki, Kanagawa 211-8533 Japan ciem@nms.ac.jp