Journal of Nippon Medical School: Vol.71 No.2 page.088

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ArticleTitle Insulin Resistance in Japanese Adolescents with Type 2 Diabetes Mellitus

AuthorList Yukashi Ohki, Megumi Kishi, Hiromi Orimo and Takuya Ohkawa

Affiliation Department of Pediatrics, Nippon Medical School

Language EN

Volume 71

Issue 2

Year 2004

Page 88-91

Received September 1, 2003

Accepted September 26, 2003

Keywords type 2 diabetes, insulin resistance, hyperinsulinemia, adolescents, oral glucose tolerance test (O-GTT)

Abstract
An oral glucose tolerance test (O-GTT) was conducted in 22 patients with type 2 diabetes mellitus whose ages at onset were less than 18 years old. They were classified into 2 groups, obese and non-obese at onset, and insulin secretory function was compared with that of a non-obese healthy group. The results show that, in the group of obese subjects with type 2 diabetes mellitus, both values of fasting IRI and ΣIRI were significantly higher than those in the healthy group. In the non-obese adolescent group with type 2 diabetes mellitus, both values of fasting IRI and ΣIRI were also significantly higher than those in the healthy group, although the difference was not as prominent as in the obese subjects with type 2 diabetes mellitus.

It was revealed that insulin resistance is present not only in obese adolescents with type 2 diabetes mellitus, but also in non-obese adolescents with type 2 diabetes mellitus.

Correspondence to Correspondence to Yukashi Ohki, Department of Pediatrics, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
yukashi@nms.ac.jp

ArticleTitle	Insulin Resistance in Japanese Adolescents with Type 2 Diabetes Mellitus
AuthorList	Yukashi Ohki, Megumi Kishi, Hiromi Orimo and Takuya Ohkawa
Affiliation	Department of Pediatrics, Nippon Medical School
Language	EN
Volume	71
Issue	2
Year	2004
Page	88-91
Received	September 1, 2003
Accepted	September 26, 2003
Keywords	type 2 diabetes, insulin resistance, hyperinsulinemia, adolescents, oral glucose tolerance test (O-GTT)
Abstract	An oral glucose tolerance test (O-GTT) was conducted in 22 patients with type 2 diabetes mellitus whose ages at onset were less than 18 years old. They were classified into 2 groups, obese and non-obese at onset, and insulin secretory function was compared with that of a non-obese healthy group. The results show that, in the group of obese subjects with type 2 diabetes mellitus, both values of fasting IRI and ΣIRI were significantly higher than those in the healthy group. In the non-obese adolescent group with type 2 diabetes mellitus, both values of fasting IRI and ΣIRI were also significantly higher than those in the healthy group, although the difference was not as prominent as in the obese subjects with type 2 diabetes mellitus. It was revealed that insulin resistance is present not only in obese adolescents with type 2 diabetes mellitus, but also in non-obese adolescents with type 2 diabetes mellitus.
Correspondence to	Correspondence to Yukashi Ohki, Department of Pediatrics, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan yukashi@nms.ac.jp