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ArticleTitle | Insulin Resistance in Japanese Adolescents with Type 2 Diabetes Mellitus |
AuthorList | Yukashi Ohki, Megumi Kishi, Hiromi Orimo and Takuya Ohkawa |
Affiliation | Department of Pediatrics, Nippon Medical School |
Language | EN |
Volume | 71 |
Issue | 2 |
Year | 2004 |
Page | 88-91 |
Received | September 1, 2003 |
Accepted | September 26, 2003 |
Keywords | type 2 diabetes, insulin resistance, hyperinsulinemia, adolescents, oral glucose tolerance test (O-GTT) |
Abstract | An oral glucose tolerance test (O-GTT) was conducted in 22 patients with type 2 diabetes mellitus whose ages at onset were less than 18 years old. They were classified into 2 groups, obese and non-obese at onset, and insulin secretory function was compared with that of a non-obese healthy group. The results show that, in the group of obese subjects with type 2 diabetes mellitus, both values of fasting IRI and ΣIRI were significantly higher than those in the healthy group. In the non-obese adolescent group with type 2 diabetes mellitus, both values of fasting IRI and ΣIRI were also significantly higher than those in the healthy group, although the difference was not as prominent as in the obese subjects with type 2 diabetes mellitus. |
Correspondence to | Correspondence to Yukashi Ohki, Department of Pediatrics, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan yukashi@nms.ac.jp |
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