Journal of Nippon Medical School: Vol.71 No.6 page.379

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ArticleTitle Detection of Urine Survivin in 40 Patients with Bladder Cancer

AuthorList Ikuroh Ohsawa¹, Taiji Nishimura², Yukihiro Kondo², Go Kimura², Mitsuhiro Satoh², Ichiro Matsuzawa², Tsutomu Hamasaki² and Shigeo Ohta¹

Affiliation ¹Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School
²Department of Urology, Nippon Medical School

Language EN

Volume 71

Issue 6

Year 2004

Page 379-383

Received May 31, 2004

Accepted August 8, 2004

Keywords survivin, bladder tumor

Abstract Purpose: We investigated whether urine survivin, an inhibitor of the apoptosis protein, is useful for diagnosing bladder tumor.
Method: We measured urine survivin levels in 40 patients with bladder tumors and 9 healthy volunteers.
Results: The average urine survivin levels in the 40 patients and 9 healthy controls were not significantly different (3.802±8.669 and 1.127±1.529, respectively (p=0.3646) ). However, significantly high urine survivin levels were observed in 3 of the 40 patients, but not in healthy volunteers. Urine Cyfra 21-1 was not elevated (1.3 ng/ml) in one patient with a significantly elevated urine survivin level (33.54 ng/ml), while in two patients with elevated Cyfra (320 ng/ml and 240 ng/ml), the urine survivin level was not detectable.
Conclusion: With improvements in the sensitivity of our Elisa system for urine survivin and combined use of urine Cyfra 21-1, it is possible that urine survivin will be a useful tumor marker in detecting both new-onset and recurrent bladder tumors.

Correspondence to Taiji Nishimura, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan

ArticleTitle	Detection of Urine Survivin in 40 Patients with Bladder Cancer
AuthorList	Ikuroh Ohsawa¹, Taiji Nishimura², Yukihiro Kondo², Go Kimura², Mitsuhiro Satoh², Ichiro Matsuzawa², Tsutomu Hamasaki² and Shigeo Ohta¹
Affiliation	¹Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School ²Department of Urology, Nippon Medical School
Language	EN
Volume	71
Issue	6
Year	2004
Page	379-383
Received	May 31, 2004
Accepted	August 8, 2004
Keywords	survivin, bladder tumor
Abstract	Purpose: We investigated whether urine survivin, an inhibitor of the apoptosis protein, is useful for diagnosing bladder tumor. Method: We measured urine survivin levels in 40 patients with bladder tumors and 9 healthy volunteers. Results: The average urine survivin levels in the 40 patients and 9 healthy controls were not significantly different (3.802±8.669 and 1.127±1.529, respectively (p=0.3646) ). However, significantly high urine survivin levels were observed in 3 of the 40 patients, but not in healthy volunteers. Urine Cyfra 21-1 was not elevated (1.3 ng/ml) in one patient with a significantly elevated urine survivin level (33.54 ng/ml), while in two patients with elevated Cyfra (320 ng/ml and 240 ng/ml), the urine survivin level was not detectable. Conclusion: With improvements in the sensitivity of our Elisa system for urine survivin and combined use of urine Cyfra 21-1, it is possible that urine survivin will be a useful tumor marker in detecting both new-onset and recurrent bladder tumors.
Correspondence to	Taiji Nishimura, Department of Urology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan