Journal of Nippon Medical School: Vol.69 No.6 page.557

Journal of Nippon Medical School

Select Language
in Japanese < > in English

Full Text of this Article

in English PDF (88K)

ArticleTitle Plasma Immunoadsorption Therapy for Guillain-Barré Syndrome: Critical Day for Initiation

AuthorList Hiroyuki Takei¹, Yuichi Komaba¹, Toshihiko Araki²,Yasuhiko Iino¹ and Yasuo Katayama¹

Affiliation ¹Second Department of Internal Medicine, Nippon Medical School, ²Department of Neurology, Kawaguchi Municipal Medical Center, Saitama

Language EN

Volume 69

Issue 6

Year 2002

Page 557-563

Received January 7, 2002

Accepted July 18, 2002

Keywords immunoadsorption plasmapheresis, Guillain-Barré syndrome, timing of therapy, clinical improvement, regression analysis

Abstract
Immunoadsorption plasmapheresis (IAPP) is a method of removing circulating immune factors that is used to treat Guillain-Barré syndrome (GBS). We retrospectively analyzed the data on our GBS patients. In 21 patients treated with IAPP, linear regression analysis showed that the time from the onset of symptoms to the initiation of IAPP was correlated with the time required for improvement by one Hughes functional grade. We investigated the critical day for initiating treatment, which we defined as the day when initiation of IAPP was significantly more likely to improve function by at least one Hughes grade when compared with the outcome in patients receiving supportive therapy (non-IAPP group). The critical day was found to be day 6 after the onset of GBS.

Correspondence to Hiroyuki Takei, MD, Second Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan
h-tokei@SC4.so-net.ac.jp

ArticleTitle	Plasma Immunoadsorption Therapy for Guillain-Barré Syndrome: Critical Day for Initiation
AuthorList	Hiroyuki Takei¹, Yuichi Komaba¹, Toshihiko Araki²,Yasuhiko Iino¹ and Yasuo Katayama¹
Affiliation	¹Second Department of Internal Medicine, Nippon Medical School, ²Department of Neurology, Kawaguchi Municipal Medical Center, Saitama
Language	EN
Volume	69
Issue	6
Year	2002
Page	557-563
Received	January 7, 2002
Accepted	July 18, 2002
Keywords	immunoadsorption plasmapheresis, Guillain-Barré syndrome, timing of therapy, clinical improvement, regression analysis
Abstract	Immunoadsorption plasmapheresis (IAPP) is a method of removing circulating immune factors that is used to treat Guillain-Barré syndrome (GBS). We retrospectively analyzed the data on our GBS patients. In 21 patients treated with IAPP, linear regression analysis showed that the time from the onset of symptoms to the initiation of IAPP was correlated with the time required for improvement by one Hughes functional grade. We investigated the critical day for initiating treatment, which we defined as the day when initiation of IAPP was significantly more likely to improve function by at least one Hughes grade when compared with the outcome in patients receiving supportive therapy (non-IAPP group). The critical day was found to be day 6 after the onset of GBS.
Correspondence to	Hiroyuki Takei, MD, Second Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan h-tokei@SC4.so-net.ac.jp