最近の論文解説

研究業績（2021〜2025）

2025年

1. Kakinuma Y. Isolating and culturing neonatal cardiomyocytes. Methods Mol Biol. 2025;2894:1-6.

2024 年

2. Saw EL, Fronius M, Katare R, Kakinuma Y. Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus. Front Cardiovasc Med. 2024;11:1425534.

3. Kakinuma Y. Non-neuronal cholinergic system in the heart influences its homeostasis and an extra-cardiac site, the blood-brain barrier. Front Cardiovasc Med. 2024;11:1384637.

4. Sonobe T, Kakinuma Y. Non-neuronal cell-derived acetylcholine, a key modulator of the vascular endothelial function in health and disease. Front Cardiovasc Med. 2024;11:1388528.

5. Kakinuma Y, Sonobe T, Katare R. Editorial: The non-neuronal cholinergic system in the cardiovascular system: its influence on the heart, vasculature, and the central nervous system. Front Cardiovasc Med. 2024;11:1523385.

6. Takenaka Y, Hirasaki M, Bono H, Nakamura S, Kakinuma Y. Transcriptome analysis reveals enhancement of cardiogenesis-related signaling pathways by S-nitroso-N-pivaloyl-d-penicillamine: implications for improved diastolic function and cardiac performance. J Cardiovasc Pharmacol. 2024;83(5):433-445.

7. Takenaka Y, Kakinuma Y, Ikeda M, Inoue I. Shared mechanisms in Pparg1sv and Pparg2 expression in 3T3-L1 cells: studies on epigenetic and positive feedback regulation of Pparg during adipogenesis. PPAR Res. 2024;2024:5518933.

8. Nemoto T. and Sagawa N. Preventation of transgenerational transmission of disease susceptibility through perinatal intervention. Endocrine J. 2004;71(3):209-222.

9. Itoh H, Aoyama T, Kohmura-Kobayashi Y, Tamura N, Nemoto T. Tauroursodeoxycholic acid as a beneficial modulator for developmentally programed chromatin structure around specific genes. Front Endocrinol (Lausanne). 2024;15:1211657.

10. Chiba Y, Takenaka Y, Haga N. Identification and characterization of the gene responsible for the O3 mating type substance in Paramecium caudatum. Microorganisms 2024;12(3):588.

11. Waddingham MT, Tsuchimochi H, Sonobe T, Sequeira V, Nayeem MJ, Shirai M, Pearson JT, Ogo T. The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension. J Mol Cell Cardiol Plus. 2024;8:100072.

2023 年

Takenaka, Y., Inoue, I., Hirasaki, M., Ikeda, M., Kakinuma, Y. “Temporal inhibition of the electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts”, FEBS Journal, vol. 290(15), pp. 3843-3857, 2023

Haga, N., Usui, T., Takenaka, Y., Chiba, Y., Abe, T. “Immaturin-Nuclease as a Model System for a Gene-Programmed Sexual Development and Rejuvenescence in Paramecium Life History”, Microorganisms, vol. 11(1), 82; https://doi.org/10.3390/microorganisms11010082, 2023

2022 年

Yamaguchi N, Kakinuma Y, Yakura T, Naito M, Okada S. Glucose infusion suppresses acute restraint stress-induced peripheral and central sympathetic responses in rats. Auton Neurosci. 2022;239:102957.

Takenaka Y, Inoue I, Nakano T, Ikeda M, Kakinuma Y. Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and subsequent mitochondrial accumulation in human fibroblasts. FEBS J. 2022;289:1650-1667.

Kurabayashi A, Furihata K, Iwashita W, Tanaka C, Fukuhara H, Inoue K, Furihata M, Kakinuma Y. Murine remote ischemic preconditioning upregulates preferentially hepatic glucose transporter-4 via its plasma membrane translocation, leading to accumulating glycogen in the liver. Life Sci. 2022;290:120261.

Maruyama T, Mano A, Ishii T, Kakinuma Y, Kaneda M. P2X2 receptors supply extracellular choline as a substrate for acetylcholine synthesis. FEBS Open Bio. 2022;12:250-257.

2021 年

Nemoto T, Kakinuma Y. Prenatal and Postnatal Methyl-Modulator Intervention Corrects the Stress-Induced Glucocorticoid Response in Low-Birthweight Rats. Int J Mol Sci. 2021 Sep 9;22(18):9767.

Nemoto T, Ando H, Nagao M, Kakinuma Y, Sugihara H. Prenatal Nicotine Exposure Induces Low Birthweight and Hyperinsulinemia in Male Rats. Front Endocrinol (Lausanne). 2021;12:694336.

Kakinuma Y. Characteristic effects of the cardiac non-neuronal acetylcholine system augmentation on brain functions. Int J Mol Sci. 2021;22(2):545.

Kakinuma Y. Significance of vagus nerve function in terms of pathogenesis of psychosocial disorders. Neurochem Int. 2021;143:104934.

Sugama S, Kakinuma Y. Noradrenaline as a key neurotransmitter in modulating microglial activation in stress response. Neurochem Int. 2021;143:104943.

Oikawa S, Kai Y, Mano A, Ohata H, Kurabayashi A, Tsuda M, Kakinuma Y. Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart. J Physiol Sci. 2021;71(1):2.

Saw EL, Pearson JT, Schwenke DO, Munasinghe PE, Tsuchimochi H, Rawal S, Coffey S, Davis P, Bunton R, Van Hout I, Kai Y, Williams MJA, Kakinuma Y, Fronius M, Katare R. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovasc Diabetol. 2021;20(1):50.

Nakano T, Aochi H, Hirasaki M, Takenaka Y, Fujita K, Tamura M, Soma H, Kamezawa H, Koizumi T, Shibuya H, Inomata R, Okuda A, Murakoshi T, Shimada A, Inoue I. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Dev Biol 2021;478:222-235

教授

柿沼 由彦

やる気のある、そして好奇心のある大学院生を募集しています。研究の題材はいくらでもありますのでご相談ください。私立大学医学部ではありますが、大学院授業料は国立大学よりも非常に安くなっており、大学院の募集要項を見て確認ください。
また、メンバーの出身大学は全員バラバラですので、他大学の方でも、他学部の方でも、まったく区別されることはありません。むしろバックグラウンドの異なる人がたくさんいるほうが、おもしろい研究になるかもしれません。

また教室独自のHpもありますので、そちらをお訪ねください。
https://sites.google.com/nms.ac.jp/bioregulatoryscience

興味がありましたら教室まで連絡いただくか、教室構成員へ直接メール等で連絡ください。